Therapeutic effects of hyaluronan on smoke-induced elastic fiber injury: does delayed treatment affect efficacy?
Therapeutic effects of hyaluronan on smoke-induced elastic fiber injury: does delayed treatment affect efficacy?
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DOI：
10.1007/s00408-010-9271-2
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发表时间：
2011-02
期刊：
影响因子：
5
通讯作者：
Turino GM
中科院分区：
文献类型：
--
作者：
Cantor JO;Cerreta JM;Ochoa M;Ma S;Liu M;Turino GM
雾化透明质酸（HA）以前已被证明可以防止香烟烟雾诱导的空域扩大和弹性纤维损伤的小鼠同时给予烟雾。在本研究中，通过延迟1个月的治疗，对HA的治疗潜力进行了更严格的测试。在用香烟烟雾每天处理3小时，每周5天，持续1个月后，小鼠（DBA/2 J）在烟雾暴露前开始接受雾化HA（0.1%）1小时（对照组给予雾化水）。结果表明，肺弹性纤维的损害发生在烟雾暴露的最初几个月内，通过测定支气管肺泡灌洗液（BALF）中锁链素和异锁链素（DID）的水平。与先前发表的研究相反，在烟雾暴露的3个月内同时施用雾化HA显著降低BALF DID水平，直到6个月HA治疗延迟时才观察到相同的效果。然而，尽管在本研究中弹性纤维的断裂时间延长，但仅在HA治疗2个月后就观察到空域扩大的显著减少。这些发现为在既存慢性阻塞性肺疾病患者中测试这种药物提供了进一步的支持。
Aerosolized hyaluronan (HA) has been previously shown to prevent cigarette smoke-induced airspace enlargement and elastic fiber injury in mice when given concurrently with smoke. In the present study, a more stringent test of the therapeutic potential of HA was performed by delaying treatment with this agent for 1 month. After treatment with cigarette smoke for 3 h per day for 5 days per week for 1 month, mice (DBA/2J) began receiving aerosolized HA (0.1%) for 1 h prior to smoke exposure (controls were given aerosolized water). The results indicate that much of the damage to the lung elastic fibers occurred within the first several months of smoke exposure, as measured by levels of desmosine and isodesmosine (DID) in bronchoalveolar lavage fluid (BALF). In contrast to previously published studies, where concurrent administration of aerosolized HA significantly reduced BALF DID levels within 3 months of smoke exposure, the same effect was not seen until 6 months when HA treatment was delayed. However, despite the prolonged breakdown of elastic fibers in the current study, a significant reduction in airspace enlargement was observed after only 2 months of HA treatment. These findings provide further support for testing this agent in patients with preexisting chronic obstructive pulmonary disease.
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影响因子：
4.3
作者：
Fiorenza, D;Viglio, S;Snider, GL
通讯作者：
Snider, GL
DOI：
10.1165/rcmb.2002-0167oc
发表时间：
2004-01-01
影响因子：
6.4
作者：
Mascarenhas, MM;Day, RM;Quinn, DA
通讯作者：
Quinn, DA
影响因子：
1.7
作者：
Nadkarni, PP;Kulkarni, GS;Cantor, JO
通讯作者：
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影响因子：
24.3
作者：
Viglio, S;Iadarola, P;Luisetti, M
通讯作者：
Luisetti, M
DOI：
10.1016/s1357-2725(02)00015-8
发表时间：
2002-06-01
影响因子：
4
作者：
Cocci, F;Miniati, M;Lungarella, G
通讯作者：
Lungarella, G