Engineering microrobots for targeted cancer therapies from a medical perspective.
Engineering microrobots for targeted cancer therapies from a medical perspective.
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DOI：
10.1038/s41467-020-19322-7
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发表时间：
2020-11-05
影响因子：
16.6
通讯作者：
Schmidt OG
中科院分区：
文献类型：
--
作者：
Schmidt CK;Medina-Sánchez M;Edmondson RJ;Schmidt OG
全身化疗仍然是许多癌症治疗的支柱。由于它的非靶向性质和它可能引起的严重副作用，已经开发了许多纳米医学方法来克服这些问题。然而，治疗剂的靶向递送仍然具有挑战性。工程微型机器人在这方面越来越受到关注。它们的功能，特别是它们的运动性，使微型机器人能够更有效地穿透组织并到达癌症。在这里，我们强调了不同的微型机器人，从量身定制的运动细菌和微小的气泡推进的微型发动机到混合精子机器人，可以被设计成整合为精确靶向广泛的癌症而优化的复杂功能。为此，我们强调在这些新技术的开发早期将临床医生、公众和癌症患者整合在一起的重要性。微机器人输送装置是试图克服与经典化疗相关的全身毒性的最新发展。本文综述了近年来该领域的研究进展，重点介绍了该研究的临床转化和潜力，并展望了该领域的未来。
Systemic chemotherapy remains the backbone of many cancer treatments. Due to its untargeted nature and the severe side effects it can cause, numerous nanomedicine approaches have been developed to overcome these issues. However, targeted delivery of therapeutics remains challenging. Engineering microrobots is increasingly receiving attention in this regard. Their functionalities, particularly their motility, allow microrobots to penetrate tissues and reach cancers more efficiently. Here, we highlight how different microrobots, ranging from tailor-made motile bacteria and tiny bubble-propelled microengines to hybrid spermbots, can be engineered to integrate sophisticated features optimised for precision-targeting of a wide range of cancers. Towards this, we highlight the importance of integrating clinicians, the public and cancer patients early on in the development of these novel technologies. Microbot delivery devices are the latest development in attempts to overcome the systemic toxicity associated with classical chemotherapy. Here, the authors review the recent progress in the field with a focus on the clinical translation and potential of the research and give a future perspective on this topic.
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影响因子：
19
作者：
Aziz, Azaam;Medina-Sanchez, Mariana;Schmidt, Oliver G.
通讯作者：
Schmidt, Oliver G.
DOI：
10.1002/adma.201706245
发表时间：
2018-05
期刊：
Advanced materials (Deerfield Beach, Fla.)
影响因子：
--
作者：
Chu D;Dong X;Shi X;Zhang C;Wang Z
通讯作者：
Wang Z
影响因子：
2.8
作者：
Cho, Sunghoon;Park, Sung Jun;Park, Sukho
通讯作者：
Park, Sukho
影响因子：
7.5
作者：
Bear, James E.;Haugh, Jason M.
通讯作者：
Haugh, Jason M.
影响因子：
16.6
作者：
Ahmed D;Baasch T;Blondel N;Läubli N;Dual J;Nelson BJ
通讯作者：
Nelson BJ