Cell-laden hydrogels for osteochondral and cartilage tissue engineering.
Cell-laden hydrogels for osteochondral and cartilage tissue engineering.
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DOI：
10.1016/j.actbio.2017.01.036
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发表时间：
2017-07-15
影响因子：
9.7
通讯作者：
Khademhosseini A
中科院分区：
文献类型：
--
作者：
Yang J;Zhang YS;Yue K;Khademhosseini A
尽管再生医学领域取得了巨大进步，但修复骨软骨界面和全层关节软骨缺损仍然具有挑战性。这种低效率很大程度上源于缺乏合适的组织工程人造基质来替代受损区域并促进组织再生。水凝胶正在成为一类有前景的软组织和硬组织再生生物材料。水凝胶的许多关键特性，如机械刚度、弹性、含水量、生物活性和降解性，可以通过适当选择材料和化学性质来合理设计和方便地调节。特别是，载有细胞的水凝胶的开发进展为细胞治疗开辟了新的可能性。在本文中，我们描述了该领域遇到的问题，并回顾了设计细胞-水凝胶混合结构以促进骨软骨/软骨组织重建的最新进展。我们的重点是水凝胶类型、细胞类型和生长因子递送对实现有效软骨形成和成骨的影响。我们提出了开发具有改善的骨软骨/软骨组织工程物理和生物特性的下一代基质的观点。我们还重点介绍了生物制造技术（例如成型、生物打印和组装）的最新进展，用于制造具有复杂成分和微结构的水凝胶骨软骨和软骨结构，以模仿其天然对应物。
Despite tremendous advances in the field of regenerative medicine, it still remains challenging to repair the osteochondral interface and full-thickness articular cartilage defects. This inefficiency largely originates from the lack of appropriate tissue engineered artificial matrices that can replace the damaged regions and promote tissue regeneration. Hydrogels are emerging as a promising class of biomaterials for both soft and hard tissue regeneration. Many critical properties of hydrogels, such as mechanical stiffness, elasticity, water content, bioactivity, and degradation, can be rationally designed and conveniently tuned by proper selection of the material and chemistry. Particularly, advances in the development of cell-laden hydrogels have opened up new possibilities for cell therapy. In this article, we describe the problems encountered in this field and review recent progress in designing cell-hydrogel hybrid constructs for promoting the reestablishment of osteochondral/cartilage tissues. Our focus centers on the effects of hydrogel type, cell type, and growth factor delivery on achieving efficient chondrogenesis and osteogenesis. We give our perspective on developing next-generation matrices with improved physical and biological properties for osteochondral/cartilage tissue engineering. We also highlight recent advances in biomanufacturing technologies (e.g. molding, bioprinting, and assembly) for fabrication of hydrogel-based osteochondral and cartilage constructs with complex compositions and microarchitectures to mimic their native counterparts.
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影响因子：
14
作者：
Bian, Liming;Zhai, David Y.;Tous, Elena;Rai, Reena;Mauck, Robert L.;Burdick, Jason A.
通讯作者：
Burdick, Jason A.
影响因子：
--
作者：
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通讯作者：
Bentley, G
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14
作者：
Awad, HA;Wickham, MQ;Guilak, F
通讯作者：
Guilak, F
影响因子：
14
作者：
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通讯作者：
Seliktar, D
影响因子：
4.1
作者：
Bian, Liming;Fong, Jason V.;Hung, Clark T.
通讯作者：
Hung, Clark T.