Chewing during prenatal stress prevents prenatal stress-induced suppression of neurogenesis, anxiety-like behavior and learning deficits in mouse offspring.
Chewing during prenatal stress prevents prenatal stress-induced suppression of neurogenesis, anxiety-like behavior and learning deficits in mouse offspring.
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DOI：
10.7150/ijms.25281
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发表时间：
2018
影响因子：
3.6
通讯作者：
Azuma K
中科院分区：
文献类型：
--
作者：
Kubo KY;Kotachi M;Suzuki A;Iinuma M;Azuma K
产前应激（PS）通过增加鼠坝中的皮质酮水平，诱导幼鼠的学习缺陷和焦虑样行为。我们检测了PS过程中母体咀嚼对小鼠幼崽精氨酸抗利尿激素（AVP） mRNA表达、神经发生、脑源性神经营养因子（BDNF） mRNA表达、学习缺陷和焦虑样行为的影响。小鼠分为对照组、应激组和应激/咀嚼组。怀孕小鼠从怀孕第12天开始受到约束应激，一直持续到分娩。应激/咀嚼组小鼠在约束应激时给予一根木棍咀嚼。PS显著提高了大鼠下丘脑室旁核（PVN） AVP mRNA的表达。PS还会损害学习能力，抑制海马神经发生和BDNF mRNA表达，并诱导后代的焦虑样行为。PS期间咀嚼可抑制PS诱导的大鼠PVN AVP mRNA表达的增加。PS期间咀嚼可显著减轻PS诱导的学习缺陷、焦虑样行为以及海马神经发生和BDNF mRNA表达的抑制。PS时咀嚼通过抑制下丘脑-垂体-肾上腺轴活性，阻止了大鼠血浆皮质酮的增加，并减轻了PS诱导的海马神经发生和BDNF表达的抑制，从而改善了PS诱导的学习缺陷和焦虑样行为。在PS期间咀嚼是一种有效的应激应对方法，可以防止PS引起的后代学习能力缺陷和焦虑样行为。
Prenatal stress (PS) induces learning deficits and anxiety-like behavior in mouse pups by increasing corticosterone levels in the dam. We examined the effects of maternal chewing during PS on arginine vasopressin (AVP) mRNA expression in the dams and on neurogenesis, brain-derived neurotrophic factor (BDNF) mRNA expression, learning deficits and anxiety-like behavior in the offspring. Mice were divided into control, stress and stress/chewing groups. Pregnant mice were exposed to restraint stress beginning on day 12 of pregnancy and continuing until delivery. Mice in the stress/chewing group were given a wooden stick to chew during restraint stress. PS significantly increased AVP mRNA expression in the paraventricular nucleus (PVN) of the hypothalamus in the dams. PS also impaired learning ability, suppressed neurogenesis and BDNF mRNA expression in the hippocampus, and induced anxiety-like behavior in the offspring. Chewing during PS prevented the PS-induced increase in AVP mRNA expression of the PVN in the dams. Chewing during PS significantly attenuated the PS-induced learning deficits, anxiety-like behavior, and suppression of neurogenesis and BDNF mRNA expression in the hippocampus of the offspring. Chewing during PS prevented the increase in plasma corticosterone in the dam by inhibiting the hypothalamic-pituitary-adrenal axis activity, and attenuated the attenuated the PS-induced suppression of neurogenesis and BDNF expression in the hippocampus of the pups, thereby ameliorating the PS-induced learning deficits and anxiety-like behavior. Chewing during PS is an effective stress-coping method for the dam to prevent PS-induced deficits in learning ability and anxiety-like behavior in the offspring.
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影响因子：
5.6
作者：
Azuma K;Zhou Q;Niwa M;Kubo KY
通讯作者：
Kubo KY
影响因子：
4.3
作者：
Epp JR;Chow C;Galea LA
通讯作者：
Galea LA
影响因子：
1.9
作者：
Gómez, FM;Giralt, MT;García-Vallejo, P
通讯作者：
García-Vallejo, P
影响因子：
2.9
作者：
Hsu, DT;Chen, FL;Kalin, NH
通讯作者：
Kalin, NH
影响因子：
2.5
作者：
HERMAN, JP
通讯作者：
HERMAN, JP