The gut-brain axis mediates bacterial driven modulation of reward signaling.
The gut-brain axis mediates bacterial driven modulation of reward signaling.
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DOI：
10.1016/j.molmet.2023.101764
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发表时间：
2023-09
影响因子：
8.1
通讯作者：
de La Serre, Claire B.
中科院分区：
文献类型：
--
作者：
Kim, Jiyoung S.;Williams, Kevin C.;Kirkland, Rebecca A.;Schade, Ruth;Freeman, Kimberly G.;Cawthon, Carolina R.;Rautmann, Allison W.;Smith, Jessica M.;Edwards, Gaylen L.;Glenn, Travis C.;Holmes, Philip V.;de Lartigue, Guillaume;de La Serre, Claire B.
我们的目标是研究微生物群组成是否调节奖励信号并评估迷走神经在介导微生物群与大脑通讯中的作用。雄性无菌Fisher大鼠的胃肠内容物定植于来自饲料（低脂（LF）ConvLF）或HF（ConvHF）喂养的大鼠的胃肠道内容物。定植后，ConvHF 大鼠比 ConvLF 大鼠消耗更多的食物。与 ConvLF 大鼠相比，ConvHF 大鼠伏核 (NAc) 中喂养诱导的细胞外 DOPAC（多巴胺的代谢物）水平较低，并且对 HF 食物的动机降低。 ConvHF 动物中 NAc 中的多巴胺受体 2 (DDR2) 表达水平也显着降低。在传统饲养的高频喂养大鼠中也观察到了类似的缺陷，这表明饮食驱动的奖励改变可以通过微生物群启动。选择性肠道到大脑的传入神经阻滞恢复了 ConvHF 大鼠的 DOPAC 水平、DRD2 表达和动机驱动。我们从这些数据中得出结论，HF 型微生物群足以改变食欲进食行为，并且奖励交流的细菌是由迷走神经介导的。 HF 型微生物群足以改变多巴胺信号传导和食欲进食行为，与饮食无关。迷走神经传入途径介导微生物群对中脑边缘多巴胺系统的影响。中脑边缘和黑质纹状体多巴胺途径均受到胃肠道细菌组成的影响。
Our goal is to investigate if microbiota composition modulates reward signaling and assess the role of the vagus in mediating microbiota to brain communication. Male germ-free Fisher rats were colonized with gastrointestinal contents from chow (low fat (LF) ConvLF) or HF (ConvHF) fed rats. Following colonization, ConvHF rats consumed significantly more food than ConvLF animals. ConvHF rats displayed lower feeding-induced extracellular DOPAC levels (a metabolite of dopamine) in the Nucleus Accumbens (NAc) as well as reduced motivation for HF foods compared to ConvLF rats. Dopamine receptor 2 (DDR2) expression levels in the NAc were also significantly lower in ConvHF animals. Similar deficits were observed in conventionally raised HF fed rats, showing that diet-driven alteration in reward can be initiated via microbiota. Selective gut to brain deafferentation restored DOPAC levels, DRD2 expression, and motivational drive in ConvHF rats. We concluded from these data that a HF-type microbiota is sufficient to alter appetitive feeding behavior and that bacteria to reward communication is mediated by the vagus nerve. A HF-type microbiota is sufficient to alter dopamine signaling and appetitive feeding behavior, independently of diet. The vagal afferent pathway mediates the effects of microbiota on the mesolimbic dopamine system. Both mesolimbic and nigrostriatal dopamine pathways are influenced by gastrointestinal bacterial make up.
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影响因子：
12.2
作者：
de Wouters d'Oplinter A;Rastelli M;Van Hul M;Delzenne NM;Cani PD;Everard A
通讯作者：
Everard A
影响因子：
5.4
作者：
Davis, C;Strachan, S;Berkson, M
通讯作者：
Berkson, M
影响因子：
2.9
作者：
Blaisdell, Aaron P.;Lau, Yan Lam Matthew;Pendergrass, David C.
通讯作者：
Pendergrass, David C.
影响因子：
4.9
作者：
Duca, F. A.;Swartz, T. D.;Covasa, M.
通讯作者：
Covasa, M.
影响因子：
5.6
作者：
Bagarolli, Renata A.;Tobar, Natalia;Saad, Mario J. A.
通讯作者：
Saad, Mario J. A.