Development trends of white matter connectivity in the first years of life.
Development trends of white matter connectivity in the first years of life.
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DOI：
10.1371/journal.pone.0024678
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Shen D
中科院分区：
文献类型：
--
作者：
Yap PT;Fan Y;Chen Y;Gilmore JH;Lin W;Shen D
人类大脑被组织成具有专门功能的交互网络的集合，以支持各种认知功能。最近的研究已经达成共识，大脑表现出小世界拓扑结构，这意味着以最小的布线成本实现全局和局部效率，以及模块化组织，这表明功能隔离和专业化。然而，小世界拓扑和模块化组织如何以及何时出现的重要问题在很大程度上仍然没有答案。以图论的方法，我们试图阐明这一问题的体内研究，使用扩散张量成像为基础的纤维束成像，在39个健康的儿科受试者的纵向数据收集的平均年龄为2周，1年，2年。我们的研究结果表明，小世界架构存在于出生时的效率，在以后的发展阶段增加。此外，我们发现这些网络在本质上是广泛的，这意味着存在关键的连接枢纽以及大脑网络对随机和有针对性的攻击的弹性。我们还观察到，随着发育，大脑网络似乎逐渐从局部的，主要是基于邻近性的连接模式演变为更分布式的，主要是基于功能的连接模式。这些观察结果表明，生命早期的大脑具有相对有效的系统，可以解决类似的信息处理问题，但方式不同。
The human brain is organized into a collection of interacting networks with specialized functions to support various cognitive functions. Recent research has reached a consensus that the brain manifests small-world topology, which implicates both global and local efficiency at minimal wiring costs, and also modular organization, which indicates functional segregation and specialization. However, the important questions of how and when the small-world topology and modular organization come into existence remain largely unanswered. Taking a graph theoretic approach, we attempt to shed light on this matter by an in vivo study, using diffusion tensor imaging based fiber tractography, on 39 healthy pediatric subjects with longitudinal data collected at average ages of 2 weeks, 1 year, and 2 years. Our results indicate that the small-world architecture exists at birth with efficiency that increases in later stages of development. In addition, we found that the networks are broad scale in nature, signifying the existence of pivotal connection hubs and resilience of the brain network to random and targeted attacks. We also observed, with development, that the brain network seems to evolve progressively from a local, predominantly proximity based, connectivity pattern to a more distributed, predominantly functional based, connectivity pattern. These observations suggest that the brain in the early years of life has relatively efficient systems that may solve similar information processing problems, but in divergent ways.
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影响因子：
5.3
作者：
Achard, S;Salvador, R;Bullmore, ET
通讯作者：
Bullmore, ET
影响因子：
4.3
作者：
Achard S;Bullmore E
通讯作者：
Bullmore E
影响因子：
3.7
作者：
Hagmann, Patric;Kurant, Maciej;Gigandet, Xavier;Thiran, Patrick;Wedeen, Van J.;Meuli, Reto;Thiran, Jean-Philippe
通讯作者：
Thiran, Jean-Philippe
影响因子：
5.7
作者：
Iturria-Medina, Yasser;Sotero, Roberto C.;Melie-Garcia, Lester
通讯作者：
Melie-Garcia, Lester
DOI：
10.1006/jmrb.1994.1037
发表时间：
1994-03-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
BASSER, PJ;MATTIELLO, J;LEBIHAN, D
通讯作者：
LEBIHAN, D