Spontaneous Primary Pleural Mesothelioma in Fischer 344 (F344) and Other Rat Strains: A Retrospective Review.
Spontaneous Primary Pleural Mesothelioma in Fischer 344 (F344) and Other Rat Strains: A Retrospective Review.
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Fischer 344（F344）和其他大鼠菌株中自发的原发性胸膜间皮瘤：回顾性综述。
DOI：
10.1177/01926233211053631
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发表时间：
2022-03
影响因子：
1.5
通讯作者：
Cesta MF
中科院分区：
文献类型：
--
作者：
Tokarz DA;Gruebbel MM;Willson GA;Hardisty JF;Pearse G;Cesta MF
在Fischer 344(F344)或其他品系的自发性胸膜间皮瘤很少被报道。这项回溯性研究的目的是开发历史发病率数据，并更好地描述这些自然发生的肿瘤在几个品系的大鼠队列中的光镜形态。对1980-2019年间进行的国家毒理学计划(NTP)大鼠研究进行了回顾，共包括104,029只大鼠(51,326只雄性，52,703只雌性)，主要是F344株(90%)。在接受调查的94,062只F344大鼠中，有30例原发性胸膜间皮瘤(雄性22只，雌性8只)。在接受调查的2998只Wistar汉族大鼠中，2只雄性大鼠出现了原发性胸膜间皮瘤。在其他品系的雄性和雌性大鼠中没有发现原发性胸膜间皮瘤(6669只SpragueDawley；300只Osborne-Mendel)。对照组和治疗组F344和Wistar汉族大鼠的所有原发性胸膜间皮瘤均被认为是自发的，与治疗无关。根据石蜡包埋切片的光镜评价，仅观察到上皮样和双相组织亚型：F344大鼠分别为18和12，Wistar汉族大鼠分别为1。在任何品系的大鼠中都没有发现肉瘤样亚型病例。
Spontaneous primary pleural mesotheliomas in Fischer 344 (F344) or other rat strains have rarely been reported. The objectives of this retrospective study were to develop historical incidence data and better characterize the light-microscopic morphology of these naturally occurring neoplasms in a large cohort of rats of several strains. A retrospective review was performed of National Toxicology Program (NTP) studies in rats conducted between 1980–2019 and comprising a total of 104,029 rats (51,326 males, 52,703 females), predominantly (90%) of the F344 strain. Of the 94,062 F344 rats surveyed, there were 30 cases of primary pleural mesotheliomas (22 males, 8 females). Of the 2998 Wistar Han rats surveyed, primary pleural mesotheliomas were present in 2 male rats. No primary pleural mesotheliomas were noted in male and female rats of other strains (6669 Sprague Dawley; 300 Osborne-Mendel). All primary pleural mesotheliomas in control and treated F344 and Wistar Han rats were considered spontaneous and unrelated to treatment. Based on light-microscopic evaluation of paraffin-embedded H&E-stained sections, only epithelioid and biphasic histologic subtypes were observed: 18 and 12 in F344 rats, respectively, and one each in Wistar Han rats. No sarcomatoid subtype cases were noted in any strain of rat.
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DOI：
10.1016/b978-0-12-391448-4.00023-x
发表时间：
2017-11-24
期刊：
Boorman's Pathology of the Rat
影响因子：
--
作者：
Herbert RA;Janardhan KS;Pandiri AR;Cesta MF;Chen V;Miller RA
通讯作者：
Miller RA
影响因子：
7.3
作者：
GOODALL, CM;CHRISTIE, GS;HURLEY, JV
通讯作者：
HURLEY, JV
影响因子：
10
作者：
Abdelgied, Mohamed;El-Gazzar, Ahmed M.;Tsuda, Hiroyuki
通讯作者：
Tsuda, Hiroyuki
影响因子：
9.6
作者：
Fraire, AE;Greenberg, SD;Roggli, VL
通讯作者：
Roggli, VL
影响因子：
1.2
作者：
Doi, Takuya;Kotani, Yuri;Tsuchitani, Minoru
通讯作者：
Tsuchitani, Minoru