Deadly COVID-19 among the elderly: Innate immune memory helping those most in need.

Deadly COVID-19 among the elderly: Innate immune memory helping those most in need.
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DOI:
10.1016/j.medj.2021.02.004
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发表时间:
2021-04-09
期刊:
Med (New York, N.Y.)
影响因子:
--
通讯作者:
Netea MG
Netea MG
中科院分区:
其他
文献类型:
--
作者:
Sohrabi Y;Reinecke H;Joosten LAB;Netea MG

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年龄是与 SARS-CoV-2 引起的症状严重程度相关的关键危险因素,迫切需要降低老年人的 COVID-19 发病率和死亡率。我们讨论的证据表明,通过 BCG 疫苗接种引起的训练有素的免疫力可能会改善免疫反应,并可以作为该人群对抗 COVID-19 的策略。年龄是与 SARS-CoV-2 引起的症状严重程度相关的关键危险因素,迫切需要降低老年人的 COVID-19 发病率和死亡率。我们讨论的证据表明,通过 BCG 疫苗接种引起的训练有素的免疫力可能会改善免疫反应,并可以作为该人群对抗 COVID-19 的策略。
Age is a key risk factor associated with the severity of symptoms caused by SARS-CoV-2, and there is an urgent need to reduce COVID-19 morbidity and mortality in elderly individuals. We discuss evidence suggesting that trained immunity elicited by BCG vaccination may improve immune responses and can serve as a strategy to combat COVID-19 in this population. Age is a key risk factor associated with the severity of symptoms caused by SARS-CoV-2, and there is an urgent need to reduce COVID-19 morbidity and mortality in elderly individuals. We discuss evidence suggesting that trained immunity elicited by BCG vaccination may improve immune responses and can serve as a strategy to combat COVID-19 in this population.
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