Plant-Based Nutritional Supplementation Attenuates LPS-Induced Low-Grade Systemic Activation.
Plant-Based Nutritional Supplementation Attenuates LPS-Induced Low-Grade Systemic Activation.
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DOI：
10.3390/ijms22020573
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发表时间：
2021-01-08
影响因子：
5.6
通讯作者：
Kindy MS
中科院分区：
文献类型：
--
作者：
Yu J;Zhu H;Taheri S;Mondy W;Perry S;Kindy MS
基于植物的营养补充剂已被证明可以减轻和降低急性和慢性疾病过程中的死亡率，包括糖尿病、肥胖症、心血管疾病、癌症、炎性疾病以及神经和神经退行性疾病。低水平的全身性炎症是这些痛苦的重要原因，富含植物化学物质的饮食可以减缓进展。本研究的目的是确定脂多糖（LPS）诱导的炎症对小鼠模型中葡萄糖和胰岛素耐受性、性能增强、尿新蝶呤水平和纹状体神经递质浓度变化的影响。LPS的急性和慢性注射（分别为2 mg/kg或0.33 mg/kg/天）均降低了葡萄糖和胰岛素耐受性，并升高了新蝶呤水平，这是全身炎症反应的指示。此外，纹状体神经递质水平（多巴胺和DOPAC）显着下降，而血清素（5-HT）水平基本不变。LPS导致增量负荷测试中的执行受损，这在补充植物性饮食的小鼠中被逆转，改善了它们的免疫功能并维持了骨骼肌线粒体活性。总之，植物性营养补充剂减弱了LPS注射引起的代谢变化，导致全身炎症活动，导致全身和神经系统的变化。
Plant-based nutritional supplementation has been shown to attenuate and reduce mortality in the processes of both acute and chronic disorders, including diabetes, obesity, cardiovascular disease, cancer, inflammatory diseases, and neurological and neurodegenerative disorders. Low-level systemic inflammation is an important contributor to these afflictions and diets enriched in phytochemicals can slow the progression. The goal of this study was to determine the impact of lipopolysaccharide (LPS)-induced inflammation on changes in glucose and insulin tolerance, performance enhancement, levels of urinary neopterin and concentrations of neurotransmitters in the striatum in mouse models. Both acute and chronic injections of LPS (2 mg/kg or 0.33 mg/kg/day, respectively) reduced glucose and insulin tolerance and elevated neopterin levels, which are indicative of systemic inflammatory responses. In addition, there were significant decreases in striatal neurotransmitter levels (dopamine and DOPAC), while serotonin (5-HT) levels were essentially unchanged. LPS resulted in impaired execution in the incremental loading test, which was reversed in mice on a supplemental plant-based diet, improving their immune function and maintaining skeletal muscle mitochondrial activity. In conclusion, plant-based nutritional supplementation attenuated the metabolic changes elicited by LPS injections, causing systemic inflammatory activity that contributed to both systemic and neurological alterations.
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影响因子：
4.8
作者：
Harding A;Gonder U;Robinson SJ;Crean S;Singhrao SK
通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
3.4
作者：
De Lucas, Ricardo Dantas;Caputo, Fabrizio;Latini, Alexandra
通讯作者：
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