Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study.
Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study.
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DOI：
10.3164/jcbn.09-100
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发表时间：
2010-03
影响因子：
2.4
通讯作者：
Guthrie N
中科院分区：
文献类型：
--
作者：
Nakao A;Toyoda Y;Sharma P;Evans M;Guthrie N
代谢综合征以心脏代谢危险因素为特征，包括肥胖、胰岛素抵抗、高血压和血脂异常。氧化应激在代谢综合征的发病机制中起重要作用。本研究的目的是在一项为期8周的开放标签研究中检验富氢水（1.5-2 L/天）对20名潜在代谢综合征受试者的有效性。将金属镁棒放入饮用水（氢浓度为0.55-0.65 mM）中，通过以下化学反应生成富氢水；Mg + 2H2O→Mg (OH)2 + H2。饮用富氢水8周后，大鼠尿液中抗氧化酶超氧化物歧化酶（SOD）升高39% (p<0.05)，硫代巴比妥酸活性物质（TBARS）降低43% （p<0.05）。此外，从基线到第4周，受试者的高密度脂蛋白（HDL）胆固醇增加了8%，总胆固醇/HDL-胆固醇下降了13%。在为期8周的研究中，空腹血糖水平没有变化。总之，饮用富氢水代表了一种潜在的治疗和预防代谢综合征的新策略。便携式镁棒是一种安全、简单、有效的方法，可以为研究参与者提供日常饮用的富氢水。
Metabolic syndrome is characterized by cardiometabolic risk factors that include obesity, insulin resistance, hypertension and dyslipidemia. Oxidative stress is known to play a major role in the pathogenesis of metabolic syndrome. The objective of this study was to examine the effectiveness of hydrogen rich water (1.5–2 L/day) in an open label, 8-week study on 20 subjects with potential metabolic syndrome. Hydrogen rich water was produced, by placing a metallic magnesium stick into drinking water (hydrogen concentration; 0.55–0.65 mM), by the following chemical reaction; Mg + 2H2O → Mg (OH)2 + H2. The consumption of hydrogen rich water for 8 weeks resulted in a 39% increase (p<0.05) in antioxidant enzyme superoxide dismutase (SOD) and a 43% decrease (p<0.05) in thiobarbituric acid reactive substances (TBARS) in urine. Further, subjects demonstrated an 8% increase in high density lipoprotein (HDL)-cholesterol and a 13% decrease in total cholesterol/HDL-cholesterol from baseline to week 4. There was no change in fasting glucose levels during the 8 week study. In conclusion, drinking hydrogen rich water represents a potentially novel therapeutic and preventive strategy for metabolic syndrome. The portable magnesium stick was a safe, easy and effective method of delivering hydrogen rich water for daily consumption by participants in the study.
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DOI：
10.1016/j.bbrc.2008.10.156
发表时间：
2008-12-26
影响因子：
3.1
作者：
Ohsawa, Ikuroh;Nishimaki, Kiyomi;Ohta, Shigeo
通讯作者：
Ohta, Shigeo
影响因子：
120.7
作者：
Holvoet, Paul;Lee, Duk-Hee;Jacobs, David R., Jr.
通讯作者：
Jacobs, David R., Jr.
影响因子：
7.7
作者：
Ford, ES;Mokdad, AH;Brown, DW
通讯作者：
Brown, DW
DOI：
10.1016/j.bbrc.2008.08.020
发表时间：
2008-10-24
影响因子：
3.1
作者：
Sato, Yasunori;Kajiyama, Shizuo;Ishigami, Akihito
通讯作者：
Ishigami, Akihito
DOI：
10.1080/15287399309531806
发表时间：
1993-10-01
期刊：
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH
影响因子：
--
作者：
LOFT, S;FISCHERNIELSEN, A;POULSEN, HE
通讯作者：
POULSEN, HE