Prolonged P300 Latency in Antipsychotic-Free Subjects with At-Risk Mental States Who Later Developed Schizophrenia.
Prolonged P300 Latency in Antipsychotic-Free Subjects with At-Risk Mental States Who Later Developed Schizophrenia.
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DOI：
10.3390/jpm11050327
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发表时间：
2021-04-21
影响因子：
--
通讯作者：
Suzuki M
中科院分区：
文献类型：
--
作者：
Higuchi Y;Sumiyoshi T;Tateno T;Nakajima S;Sasabayashi D;Nishiyama S;Mizukami Y;Takahashi T;Suzuki M
我们测量了具有高危精神状态 (ARMS) 受试者的 P300（一种事件相关电位），旨在确定 P300 参数是否可以预测显性精神分裂症的进展。 33 名 ARMS 受试者、39 名精神分裂症受试者和 28 名健康对照者参与了这项研究。所有受试者均未服用抗精神病药物。对患有 ARMS 的受试者进行了两年多的随访。认知功能通过精神分裂症认知简要评估（BACS）和精神分裂症认知评定量表（SCoRS）进行测量，而改良的整体功能评估（mGAF）用于评估整体功能。与健康对照者和 ARMS 受试者相比，精神分裂症患者的 P300 振幅更小，Pz 潜伏期更长。在随访期间，33 名 ARMS 受试者中有 8 名出现明显精神病 (ARMS-P)，而 25 名受试者则没有出现 (ARMS-NP)。 ARMS-P 的 P300 潜伏期明显长于 ARMS-NP。通过 BACS 和 SCoRS 测量，与 ARMS-NP 相比，在基线时，ARMS-P 引发的认知功能更差。我们还发现 ARMS 受试者的 P300 振幅和 mGAF 评分之间存在显着关系。我们的结果表明，延长 P300 潜伏期和认知障碍可作为易感个体精神分裂症后期发展的预测标志。
We measured P300, an event-related potential, in subjects with at-risk mental states (ARMS) and aimed to determine whether P300 parameter can predict progression to overt schizophrenia. Thirty-three subjects with ARMS, 39 with schizophrenia, and 28 healthy controls participated in the study. All subjects were antipsychotic-free. Subjects with ARMS were followed-up for more than two years. Cognitive function was measured by the Brief assessment of Cognition in Schizophrenia (BACS) and Schizophrenia Cognition Rating Scale (SCoRS), while the modified Global Assessment of Functioning (mGAF) was used to assess global function. Patients with schizophrenia showed smaller P300 amplitudes and prolonged latency at Pz compared to those of healthy controls and subjects with ARMS. During the follow-up period, eight out of 33 subjects with ARMS developed overt psychosis (ARMS-P) while 25 did not (ARMS-NP). P300 latency of ARMS-P was significantly longer than that of ARMS-NP. At baseline, ARMS-P elicited worse cognitive functions, as measured by the BACS and SCoRS compared to ARMS-NP. We also detected a significant relationship between P300 amplitudes and mGAF scores in ARMS subjects. Our results suggest the usefulness of prolonged P300 latency and cognitive impairment as a predictive marker of later development of schizophrenia in vulnerable individuals.
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影响因子：
3.7
作者：
Higuchi Y;Sumiyoshi T;Seo T;Miyanishi T;Kawasaki Y;Suzuki M
通讯作者：
Suzuki M
DOI：
10.1016/j.scog.2017.01.001
发表时间：
2017-03
期刊：
Schizophrenia research. Cognition
影响因子：
--
作者：
Higuchi Y;Sumiyoshi T;Seo T;Suga M;Takahashi T;Nishiyama S;Komori Y;Kasai K;Suzuki M
通讯作者：
Suzuki M
影响因子：
3.4
作者：
HALL, RCW
通讯作者：
HALL, RCW
影响因子：
5.7
作者：
Hall, Mei-Hua;Jensen, J. Eric;Oenguer, Dost
通讯作者：
Oenguer, Dost
精神病高风险状态：全面的最新评论。
影响因子：
25.8
作者：
Fusar-Poli, Paolo;Borgwardt, Stefan;Bechdolf, Andreas;Addington, Jean;Riecher-Rossler, Anita;Schultze-Lutter, Frauke;Keshavan, Matcheri;Wood, Stephen;Ruhrmann, Stephan;Seidman, Larry J.;Valmaggia, Lucia;Cannon, Tyrone;Velthorst, Eva;De Haan, Lieuwe;Cornblatt, Barbara;Bonoldi, Ilaria;Birchwood, Max;McGlashan, Thomas;Carpenter, William;McGorry, Patrick;Klosterkotter, Joachim;McGuire, Philip;Yung, Alison
通讯作者：
Yung, Alison