Examining the relationship between autistic spectrum disorder characteristics and structural brain differences seen in anorexia nervosa.
Examining the relationship between autistic spectrum disorder characteristics and structural brain differences seen in anorexia nervosa.
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DOI：
10.1002/erv.2910
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发表时间：
2022-09
影响因子：
5.3
通讯作者：
Tchanturia, Kate
中科院分区：
文献类型：
--
作者：
Halls, Daniel;Leppanen, Jenni;Kerr-Gaffney, Jess;Simic, Mima;Nicholls, Dasha;Mandy, William;Williams, Steven;Tchanturia, Kate
据报道，神经性厌食症（AN）与健康对照（HC）相比存在皮质差异;然而，尚不清楚自闭症谱系障碍（ASD）的特征是否与这些皮质差异有关。本研究的目的是检查结构措施是否与AN的ASD性状相关。共有184名女性参与者参加了这项研究; 57名急性体重不足的AN参与者（AAN），59名体重恢复的参与者（WR）和68名HC。参与者接受了结构磁共振成像以及完成自闭症诊断观察计划，第二版，以检查ASD特征。测量曲率、回旋、表面积、厚度、整体灰质和白色物质的组间差异。进行相关和回归分析，以检查皮质测量和ASD特征之间的关系。与HC和WR相比，在AAN组中观察到右侧中央后回和缘上回中的两个减少的回转簇和减少的整体灰质。ASD性状与结构指标之间不存在相关性。我们的研究结果表明，AN患者的结构差异似乎与ASD特征无关。虽然神经性厌食症中广泛的结构差异已被报道，但与自闭症特征的关系尚不清楚。在这项研究中，自闭症特征与神经性厌食症的结构测量或结构差异无关。可能的原因，我们的研究结果，包括神经性厌食症和自闭症之间的潜在生物过程的变化，以及神经性厌食症内的异质性进行了讨论，沿着与未来的工作策略。
Cortical differences have been reported in Anorexia Nervosa (AN) compared with healthy controls (HC); however, it is unclear if Autism Spectrum Disorder (ASD) characteristics are related to these cortical differences. The aim of this study was to examine if structural measures were correlated to ASD traits in AN. In total 184 female participants participated in the study; 57 acutely underweight AN participants (AAN), 59 weight‐restored participants (WR) and 68 HC. Participants underwent structural magnetic resonance imaging as well as completing the Autism Diagnostic Observation schedule, second edition to examine ASD characteristics. Group differences in curvature, gyrification, surface area, thickness, global grey matter and white matter were measured. Correlation and regression analysis were conducted to examine the relationship between cortical measures and ASD characteristics. Two decreased gyrification clusters in the right post central and supramarginal gyrus and decreased global grey matter were observed in the AAN group compared to HC and WR. No correlations between ASD traits and structural measures existed. Our results suggest structural differences seen in individuals with AN do not appear to be related to ASD characteristics. Though widespread structural differences have been reported in anorexia nervosa the relationship to autistic traits is under‐researched and unclear. In this study autistic characteristics were not correlated to structural measures or structural differences in anorexia nervosa. Possible reasons for our results including variation in underlying biological process between anorexia nervosa and autism, as well as heterogeneity within anorexia nervosa are discussed, along with strategies for future work.
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影响因子：
4.3
作者：
D'Mello AM;Stoodley CJ
通讯作者：
Stoodley CJ
DOI：
10.1016/j.jaac.2014.10.003
发表时间：
2015-01
影响因子：
13.3
作者：
Lai, Meng-Chuan;Lombardo, Michael V.;Auyeung, Bonnie;Chakrabarti, Bhismadev;Baron-Cohen, Simon
通讯作者：
Baron-Cohen, Simon
影响因子：
5.7
作者：
Bernardoni, Fabio;King, Joseph A.;Ehrlich, Stefan
通讯作者：
Ehrlich, Stefan
影响因子：
6.2
作者：
Kerr-Gaffney J;Hayward H;Jones EJH;Halls D;Murphy D;Tchanturia K
通讯作者：
Tchanturia K
影响因子：
2.3
作者：
Lavagnino, Luca;Amianto, Federico;Soares, Jair C.
通讯作者：
Soares, Jair C.