Serum nesfatin-1 levels are decreased in pregnant women newly diagnosed with gestational diabetes.
Serum nesfatin-1 levels are decreased in pregnant women newly diagnosed with gestational diabetes.
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DOI：
10.1590/2359-3997000000288
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发表时间：
2017-09
影响因子：
1.7
通讯作者：
Aral, Yalcin
中科院分区：
文献类型：
--
作者：
Ademoglu, Esra Nur;Gorar, Suheyla;Keskin, Muge;Carlioglu, Ayse;Ucler, Rifki;Erdamar, Husamettin;Culha, Cavit;Aral, Yalcin
研究新诊断妊娠期糖尿病妇女妊娠24-28周时血清nesfatin-1水平，并确定nesfatin-1与几种代谢参数的相关性。 40名在妊娠24-28周时新诊断为妊娠期糖尿病的妇女和30名年龄和孕周匹配的健康孕妇被纳入这项横断面研究。采用ELISA法分析血清nesfatin-1水平，并评估nesfatin-1与几种代谢参数之间的关系。 妊娠期糖尿病患者的血清nesfatin-1水平低于对照组孕妇（p = 0.020）。多元线性回归分析显示，nesfatin-1在妊娠期糖尿病患者中较低，与孕龄、BMI、HOMA-IR、空腹血糖和年龄无关。在相关性分析中，发现与nesfatin-1具有统计学显著相关性的唯一变量是胎龄（p = 0.015，r = 0.30）。 与妊娠24-28周的对照组相比，妊娠期糖尿病妇女的nesfatin-1水平较低，这引起了人们对妊娠期糖尿病中nesfatin-1水平的关注，并激发了该领域的进一步研究。
To investigate serum nesfatin-1 levels at 24-28 weeks of pregnancy in women newly diagnosed with gestational diabetes and determine the association of nesfatin-1 with several metabolic parameters. Forty women newly diagnosed with gestational diabetes at 24-28 weeks of pregnancy and 30 healthy pregnant women matched in age and gestational week were included in this cross-sectional study. Serum nesfatin-1 levels were analyzed using ELISA, and the relationship between nesfatin-1 and several metabolic parameters were assessed. Serum nesfatin-1 levels were found to be lower in women with gestational diabetes compared to the pregnant women in the control sample (p = 0.020). Multiple linear regression analysis revealed that nesfatin-1 was lower in participants with gestational diabetes independently from gestational age, BMI, HOMA-IR, fasting plasma glucose, and age. In correlation analysis, the only variable that was found to have a statistically significant correlation with nesfatin-1 was gestational age (p = 0.015, r = 0.30). Lower nesfatin-1 levels in women with gestational diabetes compared to the control group at 24-28 weeks of gestation draws attention to nesfatin-1 levels in gestational diabetes and motivates further research in this area.
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影响因子：
4
作者：
Foo, Kylie S.;Brauner, Hanna;Broberger, Christian
通讯作者：
Broberger, Christian
影响因子：
3.7
作者：
Deniz, Rulin;Gurates, Bilgin;Gungor, Sami
通讯作者：
Gungor, Sami
影响因子：
3.8
作者：
Boutsikou, Theodora;Briana, Despina D.;Malamitsi-Puchner, Ariadne
通讯作者：
Malamitsi-Puchner, Ariadne
DOI：
10.12659/msm.892611
发表时间：
2015-04-04
期刊：
Medical science monitor : international medical journal of experimental and clinical research
影响因子：
--
作者：
Ding S;Qu W;Dang S;Xie X;Xu J;Wang Y;Jing A;Zhang C;Wang J
通讯作者：
Wang J
影响因子：
3.7
作者：
Aslan, Mehmet;Celik, Onder;Aydin, Suleyman
通讯作者：
Aydin, Suleyman