Effects of Oral Carotenoids on Oxidative Stress: A Systematic Review and Meta-Analysis of Studies in the Recent 20 Years.
Effects of Oral Carotenoids on Oxidative Stress: A Systematic Review and Meta-Analysis of Studies in the Recent 20 Years.
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DOI：
10.3389/fnut.2022.754707
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发表时间：
2022
影响因子：
5
通讯作者：
Chen, Hong-Duo
中科院分区：
文献类型：
--
作者：
Zhuang, Chengfei;Yuan, Jinping;Du, Yimei;Zeng, Jing;Sun, Yan;Wu, Yan;Gao, Xing-Hua;Chen, Hong-Duo
类胡萝卜素保护器官、组织和细胞免受单线态氧、氧自由基和脂质过氧化物的破坏作用。本系统综述旨在评价口服类胡萝卜素对人类受试者的抗氧化/氧化标志物、血类胡萝卜素水平和脂质/脂蛋白参数的影响。对PubMed、Web of Sciences和科克伦图书馆2000年至2020年12月的相关文献进行了全面综述。确定了随机对照试验、病例对照试验或对照试验。共纳入18项试验，其中16项研究的目标人群为健康受试者，1项研究为运动员，1项研究为孕妇。荟萃分析结果显示，类胡萝卜素复合物补充显著增加了血浆抗氧化参数铁还原能力（FRAP）和氧自由基吸收能力（ORAC）的水平[标准化平均差异（SMD）= 0.468; 95%CI：0.159-0.776，p = 0.003; SMD = 0.568; 95%CI：0.190-0.947，p = 0.003]并降低血液甘油三酯（TG）水平（SMD = −0.410，95% CI：−0.698至−0.122，p = 0.005）。口服类胡萝卜素补充剂显著增加了血液中β-胡萝卜素（SMD = 0.490，95%CI：0.123-0.858，p = 0.009）和α-生育酚（SMD = 0.752，95%CI：0.020-1.485，p = 0.044）的水平，摄入时间为8周。抗氧化酶水平和其他脂质/脂蛋白参数在接受类胡萝卜素的受试者和对照组之间没有差异（p > 0.05）。总之，我们的系统评价表明，类胡萝卜素复合物通过与自由基相互作用或降低血液TG水平，有利于减轻潜在的氧化应激。类胡萝卜素的摄入时间应为8周，以达到足够的功能浓度。
Carotenoids protect organs, tissues, and cells from the damaging action of singlet oxygen, oxygen radicals, and lipid peroxides. This systematic review was sought to evaluate the influence of oral carotenoids on antioxidant/oxidative markers, blood carotenoids levels, and lipid/lipoprotein parameters in human subjects. A comprehensive review of relevant literature was conducted in PubMed, Web of Sciences, and the Cochrane library, from 2000 to December 2020. Randomized controlled trials, case-controlled trials, or controlled trials were identified. A total of eighteen trials were included, with the target populations being healthy subjects in 16 studies, athletes in 1 study, and pregnant women in 1 study. The meta-analysis results showed that carotenoids complex supplementation significantly increased the levels of antioxidative parameters ferric-reducing ability of plasma (FRAP) and oxygen radical absorbance capacity (ORAC) [standardized mean difference (SMD) = 0.468; 95% CI: 0.159–0.776, p = 0.003; SMD = 0.568; 95% CI: 0.190–0.947, p = 0.003] and decreased the blood triglyceride (TG) level (SMD = −0.410, 95% CI: −0.698 to −0.122, p = 0.005). Oral carotenoids supplement significantly increased the blood levels of β-carotene (SMD = 0.490, 95% CI: 0.123–0.858, p = 0.009), α-tocopherol (SMD = 0.752, 95%CI: 0.020–1.485, p = 0.044), and the intaking durations were 8 weeks. The levels of antioxidative enzymes and other lipid/lipoprotein parameters were not different between subjects receiving carotenoids and controls (p > 0.05). In conclusion, our systematic review showed that the carotenoids complex is beneficial for alleviating potential oxidative stress via interacting with free radicals or decreasing blood TG levels. The intaking duration of carotenoids should be 8 weeks to reach enough concentration for function.
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DOI：
10.3390/molecules190914794
发表时间：
2014-09-17
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Balcerczyk A;Gajewska A;Macierzyńska-Piotrowska E;Pawelczyk T;Bartosz G;Szemraj J
通讯作者：
Szemraj J
影响因子：
5.6
作者：
Cornelius C;Koverech G;Crupi R;Di Paola R;Koverech A;Lodato F;Scuto M;Salinaro AT;Cuzzocrea S;Calabrese EJ;Calabrese V
通讯作者：
Calabrese V
影响因子：
4.2
作者：
Alaluf, S;Heinrich, U;Wiseman, S
通讯作者：
Wiseman, S
影响因子：
4
作者：
Kirkwood, Thomas B. L.;Kowald, Axel
通讯作者：
Kowald, Axel
影响因子：
7.1
作者：
FULLER, CJ;FAULKNER, H;ROE, DA
通讯作者：
ROE, DA