Weight Cycling and Knee Joint Degeneration in Individuals with Overweight or Obesity: Four-Year Magnetic Resonance Imaging Data from the Osteoarthritis Initiative.
Weight Cycling and Knee Joint Degeneration in Individuals with Overweight or Obesity: Four-Year Magnetic Resonance Imaging Data from the Osteoarthritis Initiative.
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DOI：
10.1002/oby.23129
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发表时间：
2021-05
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研究超重和肥胖个体在4年内体重变化模式不同的情况下，体重循环与膝关节退行性变之间的关系。对来自骨关节炎倡议数据库的2271名个体进行了评估（病例对照研究）。使用4年内每年BMI测量的线性回归模型将参与者分类为“体重循环者”或“非循环者”。所有受试者在4年内每年使用3T MRI定量膝关节软骨T2和厚度。在基线和4年随访时，获得958例受试者的软骨、半月板和骨髓异常的全器官磁共振成像评分（蠕虫）。使用一般估计方程评估“体重循环者”和“非循环者”之间软骨T2和厚度的纵向差异，而使用一般线性模型比较蠕虫结局的差异。“体重循环者”与“非循环者”之间的软骨厚度或T2变化率无显著差异。然而，最大软骨蠕虫评分（p=0.0025）和骨髓异常（p=0.04）的增加在“体重循环者”与“非循环者”中显著更大。虽然参与者在这项研究中进行体重循环的意图尚不清楚，但与“非循环者”相比，“体重循环者”在四年内软骨和骨髓异常的增加显着更大，与体重增加和减轻无关。
To investigate the associations between weight cycling and knee joint degeneration in overweight and obese individuals with different patterns of weight change over 4 years. 2271 individuals from the Osteoarthritis Initiative Database were assessed (case-control study). Linear regression models using annual BMI measurements over 4 years were used to classify participants as “weight-cyclers” or “non-cyclers”. 3T MRI was used to quantify knee cartilage T2 and thickness annually over 4 years in all subjects. Whole-organ magnetic resonance imaging scores (WORMS) were obtained for cartilage, meniscus, and bone marrow abnormalities in 958 subjects at baseline and 4-year follow-up. The longitudinal differences in cartilage T2 and thickness between “weight-cyclers” and “non-cyclers” were assessed using general estimating equations, while the differences in WORMS outcomes were compared using general linear models. No significant differences in the rate of change of cartilage thickness or T2 were found between “weight-cyclers” vs. “non-cyclers”. However, increases in maximum cartilage WORMS scores(p=0.0025) and bone marrow abnormalities(p=0.04) were significantly greater in “weight-cyclers” vs. “non-cyclers”. While participant’s intent for weight-cycling in this study was unknown, “weight-cyclers” had significantly greater increases in cartilage and bone marrow abnormalities over four years compared to “non-cyclers”, independent of weight gain and loss.
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影响因子：
24
作者：
Gadde KM;Martin CK;Berthoud HR;Heymsfield SB
通讯作者：
Heymsfield SB
影响因子：
7
作者：
Pearle, A. D.;Scanzello, C. R.;Crow, M. K.
通讯作者：
Crow, M. K.
影响因子：
2.8
作者：
Razmjoo, Alaleh;Caliva, Francesco;Pedoia, Valentina
通讯作者：
Pedoia, Valentina
影响因子：
7
作者：
Peterfy CG;Schneider E;Nevitt M
通讯作者：
Nevitt M
DOI：
10.1111/obr.12173
发表时间：
2014-07
期刊：
Obesity reviews : an official journal of the International Association for the Study of Obesity
影响因子：
--
作者：
Bliddal H;Leeds AR;Christensen R
通讯作者：
Christensen R