Effect of Age and Acute-Moderate Intensity Exercise on Biomarkers of Renal Health and Filtration.
Effect of Age and Acute-Moderate Intensity Exercise on Biomarkers of Renal Health and Filtration.
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在本研究手稿中，作者证明，在不同年龄的健康个体中进行急性中等强度有氧运动后评估肾脏健康和滤过时，只有肾功能通过当代生物标志物胱抑素C改变，表明肾滤过的实际变化不仅仅是由于传统肾功能标志物中观察到的浓度变化。这项研究的临床应用是了解中年时期保持良好健康在预防肾功能衰退方面的价值。此外，健康的个体似乎对可以获得多高的肾脏健康和滤过有限制，并且在没有心脏代谢疾病的情况下，运动对肾脏健康和滤过的影响最小。有氧运动在健康人群和患病人群中都能促进许多生理改善。然而，肾脏健康和有氧运动滤过的急性变化仍然难以通过传统生物标志物量化以估计肾小球滤过率（eGFR）。本研究旨在确定与无心脏代谢疾病个体的肾脏健康和滤过的传统生物标志物相比，急性中等强度有氧运动是否短暂改善非传统生物标志物。39名参与者（n = 18名男性; n = 21名女性;年龄32.5 ± 12.6岁;身高171.1 ± 11.4 cm;体重78.7 ± 15.6 kg; BMI 27.1 ± 5.8）完成了一次中等强度（50- 60%HRR）有氧运动。在运动前和运动后采集血液和尿液样本并进行比较。测定血清肌酐、尿表皮生长因子（uEGF）、uEGF/尿肌酐比值（uEGFR）和胱抑素C（CyC）。此外，使用eGFR-MDRD和CKD流行病学方程分析肾脏清除率。相对于运动前测量：血清肌酐（p = 0.26），uEGF（p = 0.35）和uEGFR（p = 0.09）保持不变，而胱抑素C（p = 0.00）运动后显著增加。CyC eGFR是肾滤过显著变化的唯一估计值（p = 0.04）。总之，CyC是有氧运动后肾脏健康和滤过率显著增加的唯一生物标志物。需要进一步研究采样时间和运动强度，以巩固目前对肾脏健康和滤过的理解。
In this research manuscript, the authors demonstrate that when assessing renal health and filtration after an acute bout of moderate-intensity aerobic exercise in healthy individuals of varying ages, only renal function is altered via contemporary biomarker cystatin C, indicating actual changes in renal filtration are not solely due to concentration changes seen in traditional markers of renal function. The clinical application of this study is understanding the value that maintaining good health through the middle-age years offers in the prevention of renal decline. Additionally, healthy individuals appear to have a limit on how high renal health and filtration can be obtained, and in the absence of cardiometabolic diseases, exercise minimally influences renal health and filtration. Aerobic exercise elicits a multitude of physiological improvements in both healthy and diseased populations. However, acute changes in renal health and filtration with aerobic exercise remain difficult to quantify by traditional biomarkers to estimate glomerular filtration rate (eGFR). This study aimed to determine if an acute bout of moderate-intensity aerobic exercise transiently improves non-traditional biomarkers when compared to traditional biomarkers of renal health and filtration in individuals without cardiometabolic diseases. Thirty-nine participants (n = 18 men; n = 21 women; age 32.5 + 12.6 yr; height 171.1 + 11.4 cm; weight 78.7 + 15.6 kg; BMI 27.1 + 5.8) completed a single bout of moderate-intensity (50–60% HRR) aerobic exercise. Blood and urine samples were collected and compared before and post-exercise. Serum creatinine, urine epidermal growth factor (uEGF), uEGF/urine creatinine ratio (uEGFR), and cystatin C (CyC) were measured. In addition, eGFR-MDRD and the CKD-epidemiology equations were used to analyze renal clearance. Relative to pre-exercise measures: serum creatinine (p = 0.26), uEGF (p = 0.35), and uEGFR (p = 0.09) remained unchanged, whereas cystatin C (p = 0.00) significantly increased post-exercise. CyC eGFR was the only estimator of renal filtration to significantly change (p = 0.04). In conclusion, CyC is the only biomarker of renal health and filtration to significantly increase after aerobic exercise. Further investigation focused on sampling time and exercise-intensity is needed to solidify the current understanding of renal health and filtration.
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影响因子：
4
作者：
Leite, Joao Costa;Forte, Roberta;Gibney, Eileen R.
通讯作者：
Gibney, Eileen R.
影响因子：
2.3
作者：
Delanaye P;Cavalier E;Moranne O;Lutteri L;Krzesinski JM;Bruyère O
通讯作者：
Bruyère O
DOI：
10.1249/mss.0b013e3181b117ca
发表时间：
2010-02-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Donges, Cheyne E.;Duffield, Rob;Drinkwater, Eric J.
通讯作者：
Drinkwater, Eric J.
影响因子：
1.1
作者：
Odutayo, Ayodele;Cherney, David
通讯作者：
Cherney, David
影响因子：
0.8
作者：
Afshar, R;Shegarfy, L;Sanavi, S
通讯作者：
Sanavi, S