Optimized Electrode Placements for Non-invasive Electrical Stimulation of the Olfactory Bulb and Olfactory Mucosa.
Optimized Electrode Placements for Non-invasive Electrical Stimulation of the Olfactory Bulb and Olfactory Mucosa.
复制标题
DOI：
10.3389/fnins.2020.581503
复制
发表时间：
2020
影响因子：
4.3
通讯作者：
Datta A
中科院分区：
文献类型：
--
作者：
Cakmak YO;Nazim K;Thomas C;Datta A
众所周知，嗅觉系统在帕金森氏病(PD)和阿尔茨海默病(AD)的早期阶段功能失调。研究还表明，完好的嗅觉功能可能是脑损伤后恢复意识的关键因素。多年来，人们通过电刺激成功地尝试了对嗅觉区域的调制，无论是直接(经鼻中、术中、鼻内等)。或者间接地通过迷走神经。我们试图开发一种方法，以一种非侵入性的方式，以一种更简单、更容易、更不麻烦的方式向嗅觉区域提供优化的电刺激。最终目标是开发一种系统，允许在未来的临床试验中进行更容易的测试，这为充分开发这一潜在的治疗方案提供了机会。我们设计了六种可能的电极放置，利用了普遍接受的电刺激事实，通过相对较高的传导通路更容易进入大脑，以及实用性。使用超高分辨率有限元模型，我们筛选了这些蒙太奇中的每一个，以确定它们主要针对嗅觉区域的能力，然后筛选与PD和AD发病相关的特定皮质下区域的能力。模拟结果表明，某些位置确实会在感兴趣的区域产生有意义的电场大小。提出了一种实用的头盔概念，以实现最理想的配置。我们的结果为开发第一个针对嗅觉区域的非侵入性电刺激可穿戴系统铺平了道路，该系统可以帮助缓解症状或抑制这些神经疾病的进展。
The olfactory system is known to be dysfunctional in the early stages of Parkinson’s disease (PD) and Alzheimer’s disease (AD). It is also shown that intact olfactory function can be a key role player for regaining consciousness after brain injuries. Modulation of the olfactory regions has been attempted successfully with electrical stimulation over the years, either directly (transethmoidally, intraoperatively, internasally, etc.) or indirectly through the vagus nerve. We sought to develop a means of delivering optimized electrical stimulation to the olfactory region in a non-invasive fashion and in a way that is simpler, easier, and less cumbersome. The ultimate goal was to develop a system that would allow easier testing in future clinical trials presenting an opportunity to fully develop this potential treatment option. We devised six potential electrode placements leveraging commonly accepted facts of electrical stimulation, easier access through relatively higher conductive pathways into the brain, and practicality. Using an ultra-high-resolution finite element model, we screened each one of these montages for their ability to target the olfactory regions primarily and thereafter for select sub-cortical regions implicated in the pathogenesis of PD and AD. Modeling results indicate that some placements do result in inducing meaningful electric field magnitudes in the regions of interest. A practical headgear concept is proposed to realize the most ideal configuration. Our results pave the way for developing the first non-invasive electrical stimulation wearable system for targeting the olfactory regions which can help to alleviate the symptoms or suppress the progression of these neurological disorders.
登录
查看更多内容
影响因子：
5.7
作者：
Edwards, Dylan;Cortes, Mar;Datta, Abhishek;Minhas, Preet;Wassermann, Eric M.;Bikson, Marom
通讯作者：
Bikson, Marom
影响因子：
3.8
作者：
Doty RL;Kamath V
通讯作者：
Kamath V
影响因子：
56.9
作者：
Fyhn, M;Molden, S;Moser, MB
通讯作者：
Moser, MB
影响因子：
2.9
作者：
HABETS, AMMC;LOPESDASILVA, FH;MOLLEVANGER, WJ
通讯作者：
MOLLEVANGER, WJ
影响因子：
64.8
作者：
Arzi, Anat;Rozenkrantz, Liron;Sobel, Noam
通讯作者：
Sobel, Noam