Neurokinin B administration induces hot flushes in women.
Neurokinin B administration induces hot flushes in women.
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DOI：
10.1038/srep08466
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发表时间：
2015-02-16
影响因子：
4.6
通讯作者：
Dhillo WS
中科院分区：
文献类型：
--
作者：
Jayasena CN;Comninos AN;Stefanopoulou E;Buckley A;Narayanaswamy S;Izzi-Engbeaya C;Abbara A;Ratnasabapathy R;Mogford J;Ng N;Sarang Z;Ghatei MA;Bloom SR;Hunter MS;Dhillo WS
神经激肽B （Neurokinin B， NKB）是一种优先结合神经激肽3受体的下丘脑神经肽。编码NKB的基因表达在绝经后妇女中升高。此外，啮齿动物研究表明，NKB信号传导可能介导更年期潮热。然而，NKB对人体潮热的影响尚未进行研究。为了解决这个问题，我们进行了一项随机、双盲、安慰剂对照、双向交叉研究。10名健康女性被送入温度和湿度控制的研究单元。参与者按随机顺序接受30分钟静脉输注NKB和载体。采用双盲法比较NKB和对照组的症状、心率、血压、出汗和皮肤温度。10名参与者中有8名在NKB输注期间出现潮红，而在车辆输注期间没有人出现潮红（P = 0.0007）。在潮热发作期间，观察到心率（P = 0.0106，与症状前相比）、皮肤温度（P = 0.0258，与症状前相比）和热成像（P = 0.0491，与症状前相比）显著升高。我们的研究结果提供了证据，证明服用NKB会导致女性潮热。需要进一步的研究来确定NKB信号的药物阻断是否可以抑制更年期和性类固醇依赖性癌症治疗期间的潮热。
Neurokinin B (NKB) is a hypothalamic neuropeptide binding preferentially to the neurokinin 3 receptor. Expression of the gene encoding NKB is elevated in postmenopausal women. Furthermore, rodent studies suggest that NKB signalling may mediate menopausal hot flushes. However, the effects of NKB administration on hot flushes have not been investigated in humans. To address this, we performed a randomised, double-blinded, placebo-controlled, 2-way cross-over study. Ten healthy women were admitted to a temperature and humidity-controlled research unit. Participants received 30 minute intravenous infusions of NKB and vehicle in random order. Symptoms, heart rate, blood pressure, sweating and skin temperature were compared between NKB and vehicle in a double-blinded manner. Eight of ten participants experienced flushing during NKB infusion with none experiencing flushing during vehicle infusion (P = 0.0007). Significant elevations in heart rate (P = 0.0106 vs. pre-symptoms), and skin temperature measured using skin probe (P = 0.0258 vs. pre-symptoms) and thermal imaging (P = 0.0491 vs. pre-symptoms) characteristic of menopausal flushing were observed during hot flush episodes. Our findings provide evidence that NKB administration can cause hot flushes in women. Further studies are required to determine if pharmacological blockade of NKB signalling could inhibit hot flushes during the menopause and during treatment for sex-steroid dependent cancers.
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影响因子：
3.2
作者：
Bahr DE;Webster JG;Grady D;Kronenberg F;Creasman J;Macer J;Shults M;Tyler M;Zhou X
通讯作者：
Zhou X
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作者：
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LaCroix, Andrea Z.
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通讯作者：
Hunter, M. S.
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作者：
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通讯作者：
Blacker, CM
影响因子：
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作者：
KRAEGEN, EW;LAZARUS, L;CHIA, YO
通讯作者：
CHIA, YO