Genome-wide analysis of CCCH zinc finger family in Arabidopsis and rice.
Genome-wide analysis of CCCH zinc finger family in Arabidopsis and rice.
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拟南芥和水稻 CCCH 锌指家族的全基因组分析。
DOI：
10.1186/1471-2164-9-44
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发表时间：
2008-01-27
期刊：
影响因子：
4.4
通讯作者：
Zheng C
中科院分区：
文献类型：
--
作者：
Wang D;Guo Y;Wu C;Yang G;Li Y;Zheng C
CCCH家族中的基因编码含有三个半胱氨酸和一个组氨酸残基的基序的锌指蛋白。已知它们在动物中作为RNA结合蛋白在RNA加工中发挥重要作用。迄今为止，很少有植物CCCH蛋白的功能进行了研究。在这项研究中，一个全面的计算分析确定了68和67 CCCH家族基因在拟南芥和水稻，分别。本文对拟南芥中该基因家族的基因结构、基因发生、蛋白质基序和染色体定位进行了全面的综述。此外，这些基因在拟南芥和水稻之间进行了比较分析。这些结果表明，拟南芥和水稻CCCH家族分别分为11个和8个亚家族。拟南芥基因组中的基因重复有助于CCCH基因家族的扩展。表达研究表明，CCCH蛋白表现出多种表达模式，表明不同的功能。最后，进化分析表明，一个亚科是高等植物特异性。表达谱表明，该亚家族的大多数成员受非生物或生物胁迫的调控，表明它们可能在胁迫耐受中发挥有效作用。我们的比较基因组学分析的CCCH基因和编码的蛋白质在两个模式植物物种提供了第一步，这个新兴的家庭潜在的RNA结合蛋白的功能解剖。
Genes in the CCCH family encode zinc finger proteins containing the motif with three cysteines and one histidine residues. They have been known to play important roles in RNA processing as RNA-binding proteins in animals. To date, few plant CCCH proteins have been studied functionally. In this study, a comprehensive computational analysis identified 68 and 67 CCCH family genes in Arabidopsis and rice, respectively. A complete overview of this gene family in Arabidopsis was presented, including the gene structures, phylogeny, protein motifs, and chromosome locations. In addition, a comparative analysis between these genes in Arabidopsis and rice was performed. These results revealed that the CCCH families in Arabidopsis and rice were divided into 11 and 8 subfamilies, respectively. The gene duplication contributed to the expansion of the CCCH gene family in Arabidopsis genome. Expression studies indicated that CCCH proteins exhibit a variety of expression patterns, suggesting diverse functions. Finally, evolutionary analysis showed that one subfamily is higher plant specific. The expression profile indicated that most members of this subfamily are regulated by abiotic or biotic stresses, suggesting that they could have an effective role in stress tolerance. Our comparative genomics analysis of CCCH genes and encoded proteins in two model plant species provides the first step towards the functional dissection of this emerging family of potential RNA-binding proteins.
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影响因子：
7
作者：
Blanc, G;Hokamp, K;Wolfe, KH
通讯作者：
Wolfe, KH
影响因子：
14.9
作者：
Bakheet T;Williams BR;Khabar KS
通讯作者：
Khabar KS
DOI：
10.1002/prot.340170405
发表时间：
1993-12-01
期刊：
PROTEINS-STRUCTURE FUNCTION AND GENETICS
影响因子：
--
作者：
BORK, P
通讯作者：
BORK, P
影响因子：
3.5
作者：
De, J;Lai, WS;Blackshear, PJ
通讯作者：
Blackshear, PJ
影响因子：
3.5
作者：
Becerra, C;Jahrmann, T;Vicient, CM
通讯作者：
Vicient, CM