Introduction to Single-Cell DNA Methylation Profiling Methods.

Introduction to Single-Cell DNA Methylation Profiling Methods.
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DOI:
10.3390/biom11071013
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发表时间:
2021-07-10
期刊:
影响因子:
5.5
通讯作者:
Bang D
Bang D
中科院分区:
生物学2区
文献类型:
--
作者:
Ahn J;Heo S;Lee J;Bang D

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DNA methylation is an epigenetic mechanism that is related to mammalian cellular differentiation, gene expression regulation, and disease. In several studies, DNA methylation has been identified as an effective marker to identify differences between cells. In this review, we introduce single-cell DNA-methylation profiling methods, including experimental strategies and approaches to computational data analysis. Furthermore, the blind spots of the basic analysis and recent alternatives are briefly described. In addition, we introduce well-known applications and discuss future development.
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