Quantitative magnetic resonance imaging of meniscal pathology ex vivo.
Quantitative magnetic resonance imaging of meniscal pathology ex vivo.
复制标题
DOI：
10.1007/s00256-021-03808-6
复制
发表时间：
2021-12
影响因子：
2.1
通讯作者：
Chung CB
中科院分区：
文献类型：
--
作者：
Bae WC;Tadros AS;Finkenstaedt T;Du J;Statum S;Chung CB
确定常规自旋回波（SE）T2和超短回波时间（UTE）T2* 弛豫时间表征尸体半月板样本病理的能力。从10名人类供体中，收获了54个三角形（径向切割）半月板样本。使用改良的关节镜分级系统将半月板病理分类为正常（n = 17）、基质内退化（n = 33）或撕裂（n = 4）。采用3-T MR系统，测量脑组织的SE T2和UTE T2* 值，并进行组织病理学检查。确定了组织病理学对弛豫时间和组织学评分的影响，沿着弛豫时间和组织学评分之间的相关性。正常、退化和撕裂性髂动脉的平均±标准差UTE T2* 值分别为3.6 ± 1.3 ms、7.4 ± 2.5 ms和9.8 ± 5.7 ms，与正常髂动脉相比，退化性髂动脉（p < 0.0001）和撕裂性髂动脉（p = 0.0002）显著更高。相比之下，相应的平均SE T2值为27.7 ± 9.5 ms、25.9 ± 7.0 ms和35.7 ± 10.4 ms，组间无显著差异（所有p > 0.14）。在组织学方面，我们发现纤维组织和内尖端表面完整性分项评分以及总分存在显著的组间差异（均为p < 0.05）。最后，我们发现，与SE T2和组织学之间的相关性（p = 0.09，Rs 2 = 0.05）不同，UTE T2* 和组织学总评分之间存在显著的弱相关性（p = 0.007，Rs 2 = 0.19）。发现UTE T2* 值可区分正常与退化和撕裂的椎间盘，并与组织病理学显著相关。
To determine the ability of conventional spin echo (SE) T2 and ultrashort echo time (UTE) T2* relaxation times to characterize pathology in cadaveric meniscus samples. From 10 human donors, 54 triangular (radially cut) meniscus samples were harvested. Meniscal pathology was classified as normal (n = 17), intrasubstance degenerated (n = 33), or torn (n = 4) using a modified arthroscopic grading system. Using a 3-T MR system, SE T2 and UTE T2* values of the menisci were determined, followed by histopathology. Effect of meniscal pathology on relaxation times and histology scores were determined, along with correlation between relaxation times and histology scores. Mean ± standard deviation UTE T2* values for normal, degenerated, and torn menisci were 3.6 ± 1.3 ms, 7.4 ± 2.5 ms, and 9.8 ± 5.7 ms, respectively, being significantly higher in degenerated (p < 0.0001) and torn (p = 0.0002) menisci compared to that in normal. In contrast, the respective mean SE T2 values were 27.7 ± 9.5 ms, 25.9 ± 7.0 ms, and 35.7 ± 10.4 ms, without significant differences between groups (all p > 0.14). In terms of histology, we found significant group-wise differences (each p < 0.05) in fiber organization and inner-tip surface integrity sub-scores, as well as the total score. Finally, we found a significant weak correlation between UTE T2* and histology total score (p = 0.007, Rs2 = 0.19), unlike the correlation between SE T2 and histology (p = 0.09, Rs2 = 0.05). UTE T2* values were found to distinguish normal from both degenerated and torn menisci and correlated significantly with histopathology.
登录
查看更多内容
影响因子：
4.4
作者：
Chang, Eric Y.;Du, Jiang;Chung, Christine B.
通讯作者：
Chung, Christine B.
影响因子：
2.9
作者：
Diaz, Eric;Chung, Christine B.;Du, Jiang
通讯作者：
Du, Jiang
影响因子：
7
作者：
Roemer, F. W.;Guermazi, A.;Felson, D. T.
通讯作者：
Felson, D. T.
影响因子：
4.4
作者：
Chang, Eric Y.;Du, Jiang;Chung, Christine B.
通讯作者：
Chung, Christine B.
影响因子：
3.3
作者：
Duvvuri, U;Reddy, R;Leigh, JS
通讯作者：
Leigh, JS