Secondhand smoke exposure and higher blood pressure in children and adolescents participating in NHANES.
Secondhand smoke exposure and higher blood pressure in children and adolescents participating in NHANES.
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DOI：
10.1016/j.ypmed.2020.106052
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发表时间：
2020-05
影响因子：
5.1
通讯作者：
Wilson KM
中科院分区：
文献类型：
--
作者：
Liu SH;Liu B;Sanders AP;Saland J;Wilson KM
我们评估了急性和间歇性二手烟（SHS）暴露与儿童和青少年血压（BP）之间的关系。我们分析了2007年至2012年期间收集的3579名8-17岁儿童和青少年参与国家健康和营养检查调查（NHANES）的横断面数据，通过血清可替宁（急性暴露的生物标志物）和尿液NNAL（4-（甲基亚硝胺）-1-（3-吡啶基）-1-丁醇，间歇暴露的生物标志物）评估SHS暴露。根据美国儿科学会制定的2017年指南计算BP评分和z评分。我们使用加权线性回归解释NHANES的复杂抽样权重，并调整社会人口统计学和临床特征。总体而言，56%的儿童是非西班牙裔白色，平均年龄为12.6岁。男孩和女孩的代表性大致相等。大约15.9%的参与者生活在吸烟的家庭中。在校正模型中，尿NNAL的四分位距（IQR）增加与舒张压（DBP）z评分升高0.099（95% CI：0.033，0.16）和收缩压（SBP）z评分升高0.094（95% CI：0.011，0.18）相关。对于血清可替宁，IQR增加与DBP z评分升高0.097（95% CI：0.020，0.17）相关，但与SBP z评分无显著相关性。可替宁和NNAL与BP的关系也因性别而异。我们的研究结果提供了一个主要的烟草特异性代谢物，NNAL，和BP Z分数之间的关系在美国儿童的全国代表性人口的第一个表征。
We assessed the relationship between acute and intermittent secondhand tobacco smoke (SHS) exposure with child and adolescent blood pressure (BP). We analyzed cross-sectional data from 3579 children and adolescents aged 8–17 participating in the National Health and Nutrition Examination Survey (NHANES) collected between 2007 and 2012, with SHS exposure assessed via serum cotinine (a biomarker for acute exposures) and urine NNAL (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, a biomarker for intermittent exposures). BP percentiles and z-scores were calculated according to the 2017 guidelines established by the American Academy of Pediatrics. We used weighted linear regression accounting for the complex sampling weights from NHANES and adjusting for socio-demographic and clinical characteristics. Overall, 56% of the children were non-Hispanic white with a mean age of 12.6 years. There was approximately equal representation of boys and girls. Approximately 15.9% of participants lived in homes where smoking was present. In adjusted models, an interquartile range (IQR) increase in urinary NNAL was associated with 0.099 (95% CI: 0.033, 0.16) higher diastolic blood pressure (DBP) z-score, and with a 0.094 (95% CI: 0.011, 0.18) higher systolic blood pressure (SBP) z-score. For serum cotinine, an IQR increase was associated with 0.097 (95% CI: 0.020, 0.17) higher DBP z-scores, but was not significantly associated with SBP z-scores. The associations of cotinine and NNAL with BP also differed by sex. Our findings provide the first characterization of the relationship between a major tobacco-specific metabolite, NNAL, and BP z-scores in a nationally representative population of US children.
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影响因子：
8.3
作者：
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通讯作者：
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