Live longer with vitamin D?
Live longer with vitamin D?
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DOI：
10.3390/nu7031871
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发表时间：
2015-03-12
期刊：
影响因子：
5.9
通讯作者：
Holick MF
中科院分区：
文献类型：
--
作者：
Gröber U;Reichrath J;Holick MF
维生素D缺乏或不足的全球负担是公众健康的重大关切。根据最近的研究，维生素D缺乏是许多慢性疾病发病机制中的重要病因。25-羟维生素D（25（OH）D）状态和总体死亡率之间是否存在联系是一个相当有争议的问题。一项新的荟萃分析证实，低25（OH）D水平与全因死亡风险显著增加相关。维生素D严重缺乏的个体的死亡率几乎是25（OH）D水平≥ 30 ng/mL（≥75 nmol/L）的个体的两倍。与先前的荟萃分析不同，该分析表明血清25（OH）D > 50 ng/mL与死亡率增加相关，这项新的分析发现，即使25（OH）D水平≥70 ng/mL，也不会增加风险。总的来说，在医疗和制药实践中，应比迄今为止更密切地关注维生素D缺乏症。这些研究的结果与建议一致，即通过健康的阳光照射方法、食用含维生素D的食物和补充维生素D制剂来改善儿童和成人的一般维生素D状况。
The global burden of vitamin D deficiency or insufficiency is of great concern for public health. According to recent studies, vitamin D deficiency is an important etiological factor in the pathogenesis of many chronic diseases. Whether or not there is a connection between 25-hydoxyvitamin D (25(OH)D) status and overall mortality is a matter of considerable debate. A new meta-analysis confirmed that low 25(OH)D levels were associated with a significant increased risk for all-cause mortality. Individuals with severe vitamin D deficiency have almost twice the mortality rate as those with 25(OH)D level ≥ 30 ng/mL, (≥75 nmol/L). Unlike previous meta-analyses which suggested that serum 25(OH)D > 50 ng/mL was associated with increased mortality, this new analysis found that there was no increased risk even when 25(OH)D levels were ≥70 ng/mL. In general, closer attention should be paid to vitamin D deficiency in medical and pharmaceutical practice than has been the case hitherto. The results of these studies are consistent with the recommendation to improve the general vitamin D status in children and adults by means of a healthy approach to sunlight exposure, consumption of foods containing vitamin D and supplementation with vitamin D preparations.
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影响因子：
4
作者：
Bendik I;Friedel A;Roos FF;Weber P;Eggersdorfer M
通讯作者：
Eggersdorfer M
影响因子：
4.2
作者：
Ganji, Vijay;Zhang, Xu;Tangpricha, Vin
通讯作者：
Tangpricha, Vin
DOI：
10.4161/derm.3.4.15292
发表时间：
2011-01-01
期刊：
DERMATO-ENDOCRINOLOGY
影响因子：
--
作者：
Godar, Dianne E.;Pope, Stanley J.;Holick, Michael F.
通讯作者：
Holick, Michael F.
DOI：
10.1136/bmj.g6330
发表时间：
2014-11-18
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Afzal S;Brøndum-Jacobsen P;Bojesen SE;Nordestgaard BG
通讯作者：
Nordestgaard BG
影响因子：
3.6
作者：
Brot, C;Vestergaard, P;Sorensen, OH
通讯作者：
Sorensen, OH