Immunohistochemical expression of oestrogen receptor in normal breast tissue
Immunohistochemical expression of oestrogen receptor in normal breast tissue
复制标题
正常乳腺组织中雌激素受体的免疫组化表达
DOI：
--
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
K. Mccarty
中科院分区：
文献类型：
--
作者：
S. Carpenter;G. Georgiade;K. Mccarty
人类的乳房在月经周期中经历了深刻的变化。雌激素受体(ER)的单细胞抗体的发展使得研究受体的含量和分布在乳腺组织的个别成分中成为可能。对41例绝经前良性病变患者行双侧乳房切除术的标本进行了评估。患者分为卵泡早期、卵泡晚期、黄体早期、黄体晚期和月经期。HSCORE是对受体抗原定位的强度和分布的半定量评估，将导管和小叶上皮作为组织平均HSCORE进行评估。ER定位于上皮细胞核，在间质中未见。卵泡期ER的受体浓度较高，但这一发现并不像单个乳房小叶之间甚至乳房之间的差异那么显着。小叶之间的这种异质性表达与给定样本的小叶内受体的相对统一表达形成了鲜明对比。
The human breast undergoes profound changes during the menstrual cycle. The development of monocloiial antibodies to oestrogen-receptors (ER) allows study of receptor content and distribution in individual components of breast tissue. Forty-one specimens from premenopausal patients who underwent bilateral mastectomy for benign conditions were evaluated. The patients were categorised into early follicular, late follicular, early luteal, late luteal, and menstrual phases. An HSCORE, a semiquantitative evaluation of the intensity and distribution of receptor antigen localisation, was evaluated for the ductal and lobular epithelia as a tissue mean HSCORE. ER localised to the nuclei of the epithelium and was not observed in stromal elements. Receptor concentration was greater for ER in the follicular phase but this finding was not as striking as differences between lobules in a single breast and even between breasts. This heterogeneous expression between lobules was in contrast to the relatively uniform expression of receptor within a lobule of a given specimen.
登录
查看更多内容
DOI：
10.1097/00006254-198510000-00017
发表时间：
1984-11
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
M. Press;N. Nousek-Goebl;W. King;A. Herbst;G. Greene
通讯作者：
M. Press;N. Nousek-Goebl;W. King;A. Herbst;G. Greene
DOI：
--
发表时间：
1986-11
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
I. Damjanov;B. Mildner;B. Knowles
通讯作者：
I. Damjanov;B. Mildner;B. Knowles
影响因子：
5.8
作者：
LESSEY, BA;KILLAM, AP;MCCARTY, KS
通讯作者：
MCCARTY, KS
影响因子：
11.2
作者：
K. Mccarty;E. Szabó;J. L. Flowers;E. Cox;G. Leight;Miller Ls;J. Konrath;J. Soper;Budwit Da-
通讯作者：
K. Mccarty;E. Szabó;J. L. Flowers;E. Cox;G. Leight;Miller Ls;J. Konrath;J. Soper;Budwit Da-
使用人雌激素单克隆抗体证明人子宫中雌激素受体的免疫细胞化学方法。
DOI：
--
发表时间：
1984
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Press,MF;Greene,GL
通讯作者：
Greene,GL