Spontaneous generation of germline characteristics in mouse fibrosarcoma cells.
Spontaneous generation of germline characteristics in mouse fibrosarcoma cells.
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小鼠纤维肉瘤细胞中生殖特征的自发产生。
DOI：
10.1038/srep00743
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发表时间：
2012
影响因子：
4.6
通讯作者：
Liu, Chunfang
中科院分区：
文献类型：
--
作者：
Ma, Zhan;Hu, Yao;Jiang, Guoying;Hou, Jun;Liu, Ruilai;Lu, Yuan;Liu, Chunfang
已发现生殖系/胚胎特异性基因在躯体肿瘤中被激活。在这项研究中，我们进一步证明了在小鼠纤维肉瘤细胞(L929细胞系)中可以存在具有生殖系功能的细胞。L929细胞自发出现早期生殖系样细胞，并进一步分化为卵母细胞样细胞。这些生殖系样细胞在体外可以发育成囊胚样结构，并在体内引起畸胎癌，这与自然生殖细胞在功能上是一致的。体细胞肿瘤生殖系样细胞的产生可能为理解体细胞具有强烈的胚胎/生殖系发育特征提供一种新的途径。肿瘤的胚系特征与恶性肿瘤的永生化、侵袭性、移行性和免疫逃逸等中心特征有关。因此，肿瘤中的生殖系样细胞可能成为肿瘤生物学、诊断和治疗的潜在靶点。
Germline/embryonic-specific genes have been found to be activated in somatic tumors. In this study, we further showed that cells functioning as germline could be present in mouse fibrosarcoma cells (L929 cell line). Early germline-like cells spontaneously appeared in L929 cells and further differentiated into oocyte-like cells. These germline-like cells can, in turn, develop into blastocyst-like structures in vitro and cause teratocarcinomas in vivo, which is consistent with natural germ cells in function. Generation of germline-like cells from somatic tumors might provide a novel way to understand why somatic cancer cells have strong features of embryonic/germline development. It is thought that the germline traits of tumors are associated with the central characteristics of malignancy, such as immortalization, invasion, migration and immune evasion. Therefore, germline-like cells in tumors might provide potential targets to tumor biology, diagnosis and therapy.
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影响因子：
4
作者：
Chen CH;Chang WF;Liu CC;Su HY;Shyue SK;Cheng WT;Chen YE;Wu SC;Du F;Sung LY;Xu J
通讯作者：
Xu J
影响因子：
3.9
作者：
Bignold, Leon P.;Coghlan, Brian L. D.;Jersmann, Hubertus Pa.
通讯作者：
Jersmann, Hubertus Pa.
影响因子：
5
作者：
Nayernia, Karim;Lee, Jae Ho;Engel, Wolfgang
通讯作者：
Engel, Wolfgang
影响因子：
3.7
作者：
Linher K;Dyce P;Li J
通讯作者：
Li J
多种肿瘤类型可能源自骨髓源性细胞
影响因子：
4.8
作者：
Liu, Chunfang;Chen, Zhongwei;Lu, Yuan
通讯作者：
Lu, Yuan