Excessive alcohol consumption and the risk of knee osteoarthritis: a prospective study from the Osteoarthritis Initiative.
Excessive alcohol consumption and the risk of knee osteoarthritis: a prospective study from the Osteoarthritis Initiative.
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DOI：
10.1016/j.joca.2022.01.011
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发表时间：
2022-05
影响因子：
7
通讯作者：
Lu, B.
中科院分区：
文献类型：
--
作者：
Liu, T.;Xu, C.;Driban, J. B.;McAlindon, T.;Eaton, C. B.;Lu, B.
在一项大型前瞻性队列研究中，研究饮酒与膝关节骨关节炎(OA)发病风险之间的关系。在骨性关节炎计划中，2846名年龄在45-79岁的参与者在基线时至少有一个膝关节没有放射学膝骨性关节炎，接受了长达96个月的随访。关于基线饮酒的信息来自Block Brief食物频率调查问卷。随访期间膝关节骨关节炎(ROA)按Kellgren-Lawrence分级0或1分至⩾2分。事件症状性骨关节炎(SxOA)定义为膝关节疼痛加重的ROA。使用COX比例风险模型评估饮酒与膝关节风险之间的独立关联。在96个月的随访中，我们在2846名受试者中确定了691个膝关节发生ROA，496个膝盖发生SxOA。与不饮酒者相比，过量饮酒与ROA(HR≥30g/d vs None=1.93，95%CI：1.2 8~2.89)和SxOA(HR≥30g/d vs None=1.6 1，95%CI：1.0 4~2.48)的风险增加显著相关。饮酒与饮酒的相关性相似(HR白酒≥15g/d vs NONE=1.71，95%CI：1.16~2.52；HR白酒≥15g/d vs None=1.5 9，95%CI：1.0 4~2.39)。轻度到中度饮酒与膝骨性关节炎风险无关。我们的结果表明，过量饮酒与膝骨性关节炎的风险增加有关。在其他人群中还需要进一步的研究。
To examine the association of alcohol consumption with risk of incident knee osteoarthritis (OA) in a large prospective cohort study. In the Osteoarthritis Initiative, 2,846 participants aged 45–79 years and free from radiographic knee OA in at least one knee at baseline were followed up to 96 months. Information on baseline alcohol consumption was obtained from the Block Brief Food Frequency Questionnaire. Incident cases of radiographic knee OA (ROA) were defined as Kellgren–Lawrence grade changing from 0 or 1 to ⩾ 2 during the follow-up time. Incident symptomatic OA (SxOA) was defined as ROA with knee pain worsening. The Cox proportional hazards models were used to assess the independent association between alcohol consumption and risk of knee. During 96 months’ follow-up, we identified 691 knees with incident ROA, and 496 knees with incident SxOA among 2,846 subjects. Compared to non-drinkers, excessive alcohol consumption was significantly associated with increased risk of ROA (HR ≥ 30g/d vs none = 1.93, 95% CI: 1.28–2.89) and SxOA (HR ≥ 30g/d vs none = 1.61, 95% CI: 1.04–2.48). Similar association was observed for liquor consumption (HR liquor ≥ 15g/d vs none = 1.71, 95% CI: 1.16–2.52 for ROA; HR liquor ≥ 15g/d vs none = 1.59, 95% CI: 1.04–2.39 for SxOA). Light to moderate alcohol consumption was not associated with knee OA risk. Our results suggest that excessive alcohol drinking was associated with an increased risk of knee OA. Further studies are needed in other populations.
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影响因子：
2.9
作者：
Zhang Y;Zeng C;Wei J;Li H;Yang T;Yang Y;Deng ZH;Ding X;Lei G
通讯作者：
Lei G
影响因子：
4.7
作者：
Panagiotakos, Demosthenes B.;Kouli, Georgia-Maria;Pitsavos, Christos
通讯作者：
Pitsavos, Christos
DOI：
10.3899/jrheum.170026
发表时间：
2017-09
期刊：
The Journal of rheumatology
影响因子：
--
作者：
Haugen IK;Magnusson K;Turkiewicz A;Englund M
通讯作者：
Englund M
影响因子：
7.2
作者：
WASHBURN, RA;SMITH, KW;JANNEY, CA
通讯作者：
JANNEY, CA
实验小鼠模型中慢性饮酒诱导骨关节炎样病理变化。
DOI：
10.1002/art.39090
发表时间：
2015-06
期刊：
Arthritis & rheumatology (Hoboken, N.J.)
影响因子：
--
作者：
Kc R;Voigt R;Li X;Forsyth CB;Ellman MB;Summa KC;Turek FW;Keshavarzian A;Kim JS;Im HJ
通讯作者：
Im HJ