Lifestyle, dietary factors, and antibody levels to oral bacteria in cancer-free participants of a European cohort study.
Lifestyle, dietary factors, and antibody levels to oral bacteria in cancer-free participants of a European cohort study.
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欧洲队列研究的无癌参与者的生活方式，饮食因素和抗体水平。
DOI：
10.1007/s10552-013-0265-2
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发表时间：
2013-11
影响因子：
2.3
通讯作者：
Bueno-de-Mesquita, H. Bas
中科院分区：
文献类型：
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作者：
Michaud, Dominique S.;Izard, Jacques;Rubin, Zachary;Johansson, Ingegerd;Weiderpass, Elisabete;Tjonneland, Anne;Olsen, Anja;Overvad, Kim;Boutron-Ruault, Marie Christine;Clavel-Chapelon, Francoise;Dossus, Laure;Kaaks, Rudolf;Katzke, Verena A.;Boeing, Heiner;Foerster, Jana;Trichopoulou, Antonia;Naska, Androniki;Ziara, Giana;Vineis, Paolo;Grioni, Sara;Palli, Domenico;Tumino, Rosario;Mattiello, Amalia;Peeters, Petra H. M.;Siersema, Peter D.;Barricarte, Aurelio;Huerta, Jose-Maria;Molina-Montes, Esther;Dorronsoro, Miren;Ramon Quiros, J.;Duell, Eric J.;Ohlsson, Bodil;Jeppsson, Bengt;Johansson, Anders;Lif, Pernilla;Khaw, Kay-Tee;Wareham, Nick;Travis, Ruth C.;Key, Tim J.;Freisling, Heinz;Duarte-Salles, Talita;Stepien, Magdalena;Riboli, Elio;Bueno-de-Mesquita, H. Bas
越来越多的证据表明，口腔微生物群在慢性疾病中起着关键作用，除了在牙周病中的作用。此外，最近的研究表明，口腔细菌也可能参与致癌作用;牙周病与几种癌症有关。在这项研究中，我们研究了生活方式因素是否会影响口腔细菌的抗体水平。在血样采集时获得人口统计学特征、生活方式因素和医疗状况的数据。对于目前的分析，我们使用免疫印迹阵列测量了395名无癌症个体中25种口腔细菌的抗体水平。通过对所有测量的口腔细菌的浓度求和获得组合的总免疫球蛋白G（IgG）水平。当前和既往吸烟者的IgG抗体水平（分别为1697和1677 ng/mL）显著低于从不吸烟者（1960 ng/mL; p趋势= 0.01），但在调整年龄、性别、教育、国家和吸烟状况后，其他因素（包括BMI、糖尿病、体力活动或饮食因素）并没有变化。总IgG水平最高的是受教育程度低的人（2419 ng/mL）。我们关于吸烟的发现与之前的研究一致，并支持吸烟者体液免疫反应受损的观点。此外，已知与炎症标志物相关的其他主要因素，包括肥胖，与大量口腔细菌的抗体水平无关。
Increasing evidence suggests that oral microbiota play a pivotal role in chronic diseases, in addition to the well-established role in periodontal disease. Moreover, recent studies suggest that oral bacteria may also be involved in carcinogenesis; periodontal disease has been linked several cancers. In this study, we examined whether lifestyle factors have an impact on antibody levels to oral bacteria. Data on demographic characteristics, lifestyle factors, and medical conditions were obtained at the time of blood sample collection. For the current analysis, we measured antibody levels to 25 oral bacteria in 395 cancer-free individuals using an immunoblot array. Combined total immunglobin G (IgG) levels were obtained by summing concentrations for all oral bacteria measured. IgG antibody levels were substantially lower among current and former smokers (1697 and 1677 ng/mL, respectively) than never smokers (1960 ng/mL; p-trend = 0.01), but did not vary by other factors, including BMI, diabetes, physical activity, or by dietary factors, after adjusting for age, sex, education, country and smoking status. The highest levels of total IgG were found among individuals with low education (2419 ng/mL). Our findings on smoking are consistent with previous studies and support the notion that smokers have a compromised humoral immune response. Moreover, other major factors known to be associated with inflammatory markers, including obesity, were not associated with antibody levels to a large number of oral bacteria.
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影响因子：
24.5
作者：
Michaud DS;Izard J;Wilhelm-Benartzi CS;You DH;Grote VA;Tjønneland A;Dahm CC;Overvad K;Jenab M;Fedirko V;Boutron-Ruault MC;Clavel-Chapelon F;Racine A;Kaaks R;Boeing H;Foerster J;Trichopoulou A;Lagiou P;Trichopoulos D;Sacerdote C;Sieri S;Palli D;Tumino R;Panico S;Siersema PD;Peeters PH;Lund E;Barricarte A;Huerta JM;Molina-Montes E;Dorronsoro M;Quirós JR;Duell EJ;Ye W;Sund M;Lindkvist B;Johansen D;Khaw KT;Wareham N;Travis RC;Vineis P;Bueno-de-Mesquita HB;Riboli E
通讯作者：
Riboli E
影响因子：
12.3
作者：
Segata N;Haake SK;Mannon P;Lemon KP;Waldron L;Gevers D;Huttenhower C;Izard J
通讯作者：
Izard J
影响因子：
--
作者：
Sakellari, D;Socransky, SS;Taubman, MA
通讯作者：
Taubman, MA
影响因子：
7
作者：
Castellarin, Mauro;Warren, Rene L.;Holt, Robert A.
通讯作者：
Holt, Robert A.
影响因子：
3.7
作者：
Hajishengallis G;Lamont RJ
通讯作者：
Lamont RJ