Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study.
Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study.
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DOI：
10.1136/gutjnl-2012-303006
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发表时间：
2013-12
期刊：
影响因子：
24.5
通讯作者：
Riboli E
中科院分区：
文献类型：
--
作者：
Michaud DS;Izard J;Wilhelm-Benartzi CS;You DH;Grote VA;Tjønneland A;Dahm CC;Overvad K;Jenab M;Fedirko V;Boutron-Ruault MC;Clavel-Chapelon F;Racine A;Kaaks R;Boeing H;Foerster J;Trichopoulou A;Lagiou P;Trichopoulos D;Sacerdote C;Sieri S;Palli D;Tumino R;Panico S;Siersema PD;Peeters PH;Lund E;Barricarte A;Huerta JM;Molina-Montes E;Dorronsoro M;Quirós JR;Duell EJ;Ye W;Sund M;Lindkvist B;Johansen D;Khaw KT;Wareham N;Travis RC;Vineis P;Bueno-de-Mesquita HB;Riboli E
在一项前瞻性队列研究中，检查25种口腔细菌抗体与胰腺癌风险之间的关系。我们检测了405例胰腺癌患者和416名匹配对照的诊断前血液样本中的口腔细菌抗体，这些样本嵌套在欧洲癌症与营养前瞻性研究(EPIC)中。使用条件Logistic回归进行分析，并对吸烟状况和体重指数进行了额外调整。牙龈卟啉单胞菌ATTC 53978抗体水平高的个体患胰腺癌的风险是抗体水平较低的个体的2倍(优势比[OR]，2.14；95%可信区间[CI]，1.05-4.36；>；200 ng/mlvs≤200 ng/ml)。为了探索与共生(非致病)口腔细菌的相关性，我们进行了聚类分析，并根据他们的抗体谱识别了两组个体。抗体水平总体较高的群体比抗体水平整体水平较低的群体患胰腺癌的风险低45%(OR，0.55；95%CI，0.36-0.83)。牙周病可能会增加患胰腺癌的风险。此外，增加针对特定共生口腔细菌的抗体水平，可以抑制病原菌的生长，可能会降低胰腺癌的风险。需要研究确定口腔细菌是否在胰腺癌的发病机制中有直接影响，或者作为免疫反应的标志。
Examine the relationship between antibodies to 25 oral bacteria and pancreatic cancer risk in a prospective cohort study. We measured antibodies to oral bacteria in prediagnosis blood samples from 405 pancreatic cancer cases and 416 matched controls, nested within the European Prospective Investigation into Cancer and Nutrition study (EPIC). Analyses were conducted using conditional logistic regression and additionally adjusted for smoking status and body mass index. Individuals with high levels of antibodies against Porphyromonas gingivalis ATTC 53978, a pathogenic periodontal bacteria, had a 2-fold higher risk of pancreatic cancer than individuals lower levels of these antibodies (odds ratio [OR], 2.14; 95% confidence interval [CI], 1.05–4.36; >200 ng/ml vs ≤200 ng/ml). To explore the association with commensal (non-pathogenic) oral bacteria, we performed a cluster analysis and identified 2 groups of individuals, based on their antibody profiles. A cluster with overall higher levels of antibodies had a 45% lower risk of pancreatic cancer than a cluster with overall lower levels of antibodies (OR, 0.55; 95% CI, 0.36–0.83). Periodontal disease might increase the risk for pancreatic cancer. Moreover, increased levels of antibodies against specific commensal oral bacteria, which can inhibit growth of pathogenic bacteria, might reduce the risk of pancreatic cancer. Studies are needed to determine whether oral bacteria have direct effects on pancreatic cancer pathogenesis or serve as markers of the immune response.
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通讯作者：
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