One Tool for Many Jobs: Divergent and Conserved Actions of Androgen Signaling in Male Internal Reproductive Tract and External Genitalia.
One Tool for Many Jobs: Divergent and Conserved Actions of Androgen Signaling in Male Internal Reproductive Tract and External Genitalia.
复制标题
DOI：
10.3389/fendo.2022.910964
复制
发表时间：
2022
影响因子：
5.2
通讯作者：
Zhao, Fei
中科院分区：
文献类型：
--
作者：
Amato, Ciro M.;Yao, Humphrey H-C.;Zhao, Fei
在20世纪40年代，阿尔弗雷德·约斯特证明了睾丸分泌物，特别是雄激素，对于男性内外生殖器分化的必要性。从那时起，我们对雄激素对男性内生殖器（沃尔夫管）和外生殖器（阴茎）分化的影响的认识得到了极大的扩展。在这两个形态和功能不同的器官之间，不同的信号有助于建立组织特异性身份。相反，雄激素信号的保守作用存在于两种组织中，并在很大程度上负责器官的生长和扩张。本文综述了雄激素的细胞特异性、器官特异性和保守性信号机制。Wolffian导管和雄性外生殖器中雄激素信号传导的机制研究已经在小鼠模型生物中进行了大量的研究。因此，大部分综述集中在小鼠模型研究上。
In the 1940s, Alfred Jost demonstrated the necessity of testicular secretions, particularly androgens, for male internal and external genitalia differentiation. Since then, our knowledge of androgen impacts on differentiation of the male internal (Wolffian duct) and external genitalia (penis) has been drastically expanded upon. Between these two morphologically and functionally distinct organs, divergent signals facilitate the establishment of tissue-specific identities. Conversely, conserved actions of androgen signaling are present in both tissues and are largely responsible for the growth and expansion of the organs. In this review we synthesize the existing knowledge of the cell type-specific, organ specific, and conserved signaling mechanisms of androgens. Mechanistic studies on androgen signaling in the Wolffian duct and male external genitalia have largely been conducted in mouse model organisms. Therefore, the majority of the review is focused on mouse model studies.
登录
查看更多内容
影响因子：
11.8
作者：
Carroll, TJ;Park, JS;McMahon, AP
通讯作者：
McMahon, AP
影响因子：
2.9
作者：
Baskin, Laurence;Shen, Joel;Cunha, Gerald R.
通讯作者：
Cunha, Gerald R.
影响因子：
2.7
作者：
Donjacour, AA;Thomson, AA;Cunha, GR
通讯作者：
Cunha, GR
影响因子：
2.7
作者：
Chiu HS;Szucsik JC;Georgas KM;Jones JL;Rumballe BA;Tang D;Grimmond SM;Lewis AG;Aronow BJ;Lessard JL;Little MH
通讯作者：
Little MH
影响因子：
4.8
作者：
COOKE, PS;YOUNG, P;CUNHA, GR
通讯作者：
CUNHA, GR