Prostaglandin E2 contributes to L. braziliensis survival and therapeutic failure in cutaneous leishmaniasis.
Prostaglandin E2 contributes to L. braziliensis survival and therapeutic failure in cutaneous leishmaniasis.
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DOI：
10.1080/22221751.2023.2261565
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发表时间：
2023-12
影响因子：
13.2
通讯作者：
Carvalho, Lucas P.
中科院分区：
文献类型：
--
作者：
Nascimento, Mauricio T.;Viana, Debora L.;Peixoto, Fabio C.;Arruda, Sergio M.;Carvalho, Edgar M.;Carvalho, Lucas P.
皮肤利什曼病（CL）患者表现出与组织损伤和溃疡发展相关的炎症反应加剧。近年来，已观察到五价锑酸盐治疗失败率较高，但其根本原因仍知之甚少。我们推测，类二十烷蛋白PGE2有利于巴西乳杆菌感染的建立，从而导致治疗失败。本研究的目的是探讨PGE2对CL患者巨噬细胞中巴西乳杆菌存活和治疗失败率的影响。PGE2是一种由环氧丙烷-2酶代谢花生四烯酸产生的类二十烷，在免疫应答中起多种作用。我们发现PGE2升高会降低巨噬细胞的杀微生物功能，并与疾病严重程度和治疗失败有关。此外，选择性非甾体抗炎药NS398对COX-2的中和作用增加了巨噬细胞杀死巴西乳杆菌的能力，并防止病理性炎症反应。我们的数据表明NS398可以作为CL患者的辅助治疗。
Patients with cutaneous leishmaniasis (CL) present an exacerbated inflammatory response associated with tissue damage and ulcer development. In recent years, higher rates of failure to pentavalent antimoniate therapy have been observed, yet the underlying reason remains poorly understood. We hypothesize that the eicosanoid PGE2 favours the establishment of infection by L. braziliensis, which contributes to therapeutic failure. The aim of the present study was to investigate the influence of PGE2 on the survival of L. braziliensis in macrophages and rates of therapeutic failure in CL patients. PGE2, an eicosanoid derived from the metabolism of arachidonic acid by the COX-2 enzyme, plays several roles in immune response. We found that increased PGE2 decreases the microbicidal function of macrophages and is associated with disease severity and therapeutic failure. Additionally, the neutralization of COX-2 by NS398, a selective NSAID, increases the ability of macrophages to kill L. braziliensis and protects against the pathological inflammatory response. Our data suggest that NS398 may serve as an adjunct treatment for CL patients.
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影响因子：
5.7
作者：
Oliveira WN;Dórea AS;Carneiro PP;Nascimento MT;Carvalho LP;Machado PRL;Schriefer A;Bacellar O;Carvalho EM
通讯作者：
Carvalho EM
影响因子：
4.6
作者：
Lonardoni MV;Barbieri CL;Russo M;Jancar S
通讯作者：
Jancar S
影响因子：
2.8
作者：
BITTENCOURT, AL;BARRAL, A
通讯作者：
BARRAL, A
影响因子：
3.7
作者：
Carneiro, Pedro Paulo;Conceicao, Jacilara;Bacellar, Olivia
通讯作者：
Bacellar, Olivia
DOI：
10.4269/ajtmh.1994.50.296
发表时间：
1994-03-01
影响因子：
3.3
作者：
CUPOLILLO, E;GRIMALDI, G;MOMEN, H
通讯作者：
MOMEN, H