Processing of pain by the developing brain: evidence of differences between adolescent and adult females.
Processing of pain by the developing brain: evidence of differences between adolescent and adult females.
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DOI：
10.1097/j.pain.0000000000002571
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发表时间：
2022-09-01
期刊：
影响因子：
7.4
通讯作者：
中科院分区：
文献类型：
--
作者：
与成年女性相比，女性青少年表现出更大的低疼痛敏感性和疼痛诱发的大脑反应，涉及伤害性，情感和认知处理的重要区域。青春期是大脑发育和慢性疼痛出现的敏感时期，尤其是女性。然而，在青春期支持疼痛感知的大脑机制仍不清楚。本研究比较了女性青少年和成年人对疼痛的知觉和大脑反应，以表征发育中大脑的疼痛处理。30名青少年（年龄13-17岁）和30名成人（年龄35-55岁）女性接受了涉及急性疼痛的功能性磁共振成像扫描。参与者接受了12个10秒的伤害性压力刺激，以2.5和4 kg/cm 2施加到左拇指甲上，并在视觉模拟量表上评定疼痛强度和不愉快。我们发现一个显着的组刺激强度的相互作用疼痛评级。与成年人相比，青少年对2.5 kg/cm 2而不是4 kg/cm 2的疼痛强度和不愉快反应更大。青少年表现出更大的内侧-外侧前额叶皮层和缘上回激活响应2.5公斤/平方厘米和更大的内侧前额叶皮层和喙前扣带回响应4公斤/平方厘米。青少年表现出更大的疼痛诱发反应的神经疼痛签名和更大的激活默认模式和腹侧注意网络。此外，杏仁核和相关区域在预测青少年疼痛强度方面发挥了更大的作用，默认模式和腹侧注意区域的活动更强烈地介导了刺激强度和疼痛评级之间的关系。这项研究提供了第一个证据，更低的疼痛敏感性和疼痛诱发的大脑反应在女性青少年（与成年女性）的伤害性，情感和认知处理，这可能与外周伤害性的差异重要的区域。
Compared with adult women, female adolescents showed greater low-pain sensitivity and pain-evoked brain responses involving regions important for nociceptive, affective, and cognitive processing. Adolescence is a sensitive period for both brain development and the emergence of chronic pain particularly in females. However, the brain mechanisms supporting pain perception during adolescence remain unclear. This study compares perceptual and brain responses to pain in female adolescents and adults to characterize pain processing in the developing brain. Thirty adolescent (ages 13-17 years) and 30 adult (ages 35-55 years) females underwent a functional magnetic resonance imaging scan involving acute pain. Participants received 12 ten-second noxious pressure stimuli that were applied to the left thumbnail at 2.5 and 4 kg/cm2, and rated pain intensity and unpleasantness on a visual analogue scale. We found a significant group-by-stimulus intensity interaction on pain ratings. Compared with adults, adolescents reported greater pain intensity and unpleasantness in response to 2.5 kg/cm2 but not 4 kg/cm2. Adolescents showed greater medial–lateral prefrontal cortex and supramarginal gyrus activation in response to 2.5 kg/cm2 and greater medial prefrontal cortex and rostral anterior cingulate responses to 4 kg/cm2. Adolescents showed greater pain-evoked responses in the neurologic pain signature and greater activation in the default mode and ventral attention networks. Also, the amygdala and associated regions played a stronger role in predicting pain intensity in adolescents, and activity in default mode and ventral attention regions more strongly mediated the relationship between stimulus intensity and pain ratings. This study provides first evidence of greater low-pain sensitivity and pain-evoked brain responses in female adolescents (vs adult women) in regions important for nociceptive, affective, and cognitive processing, which may be associated with differences in peripheral nociception.
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影响因子：
3.7
作者：
Baliki MN;Mansour AR;Baria AT;Apkarian AV
通讯作者：
Apkarian AV
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
2.5
作者：
Coghill, RC;Sang, CN;Iadarola, MJ
通讯作者：
Iadarola, MJ
影响因子：
6.6
作者：
Casey, B. J.;Getz, Sarah;Galvan, Adriana
通讯作者：
Galvan, Adriana
影响因子：
5.7
作者：
Fonov V;Evans AC;Botteron K;Almli CR;McKinstry RC;Collins DL;Brain Development Cooperative Group
通讯作者：
Brain Development Cooperative Group