Loss of motor function in preclinical Alzheimer's disease.
Loss of motor function in preclinical Alzheimer's disease.
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DOI：
10.1586/ern.11.57
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发表时间：
2011-05
影响因子：
4.3
通讯作者：
Bennett DA
中科院分区：
文献类型：
--
作者：
Buchman AS;Bennett DA
越来越多的证据表明，阿尔茨海默病（AD）有一个漫长的临床前阶段，在此期间，其特征病理积累和患者功能下降，但症状不足以保证痴呆的临床诊断。有越来越多的非认知症状的报道，包括运动功能丧失，与AD的发生有关。为了了解运动功能与临床前AD之间的联系，本文探讨了：我们对运动功能的理解及其在队列研究中的临床评估；老年人运动功能与认知功能丧失的关系认知和运动能力下降的危险因素；死后AD各项指标与死前运动功能的关系。总之，这些数据表明，与年龄相关的认知和运动能力下降可能有一个共同的原因。此外，临床诊断为阿尔茨海默氏症的个体可能代表“冰山一角”，因为阿尔茨海默氏症病理也可能解释了目前被认为是无痴呆老年人“正常衰老”的认知和运动功能障碍的很大一部分。因此，阿尔茨海默病可能对我们老年人口的健康和福祉产生更大的影响。
Accumulating evidence suggests that Alzheimer’s disease (AD) has a long preclinical phase, during which time its characteristic pathology accumulates and patient function declines, but symptoms are insufficient to warrant a clinical diagnosis of dementia. There have been increasing reports of noncognitive symptoms, including loss of motor function, reported to be associated with incident AD. To understand the link between motor function and preclinical AD, this article examines: our understanding of motor function and its clinical assessment in cohort studies; the relationship of motor function and loss of cognition in older persons; risk factors for cognitive and motor decline; and the relation of post-mortem indices of AD and motor function prior to death. Together, these data suggest that age-related cognitive and motor decline may share a common causation. Furthermore, individuals with a clinical diagnosis of AD may represent the ‘tip of the iceberg’, since AD pathology may also account for a substantial proportion of cognitive and motor dysfunction currently considered ‘normal aging’ in older persons without dementia. Thus, AD may have a much larger impact on the health and wellbeing of our aging population.
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影响因子：
11
作者：
Bennett, DA;Schneider, JA;Arnold, SE
通讯作者：
Arnold, SE
DOI：
10.1093/gerona/61.3.262
发表时间：
2006-03-01
影响因子：
5.1
作者：
Bandeen-Roche, K;Xue, QL;Fried, LP
通讯作者：
Fried, LP
影响因子：
1.8
作者：
Boyle, P. A.;Wilson, R. S.;Bennett, D. A.
通讯作者：
Bennett, D. A.
影响因子：
9.9
作者：
Arvanitakis, Z;Wilson, RS;Bennett, DA
通讯作者：
Bennett, DA
影响因子：
4.8
作者：
Agosta, Federica;Rocca, Maria Assunta;Filippi, Massimo
通讯作者：
Filippi, Massimo