Vulnerability of white matter tracts and cognition to the SOD2 polymorphism: A preliminary study of antioxidant defense genes in brain aging.
Vulnerability of white matter tracts and cognition to the SOD2 polymorphism: A preliminary study of antioxidant defense genes in brain aging.
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DOI：
10.1016/j.bbr.2017.04.041
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发表时间：
2017-06-30
影响因子：
2.7
通讯作者：
Paul RH
中科院分区：
文献类型：
--
作者：
Salminen LE;Schofield PR;Pierce KD;Bruce SE;Griffin MG;Tate DF;Cabeen RP;Laidlaw DH;Conturo TE;Bolzenius JD;Paul RH
氧化应激是衰老过程中的一个关键机制，可导致大脑白色物质和认知功能受损。超氧化物歧化酶2（SOD 2）和过氧化氢酶（CAT）基因的多态性与衰老大脑中抗氧化酶活性的异常相关，这表明具有这些遗传变异的老年人对白色物质和认知的氧化损伤增强的风险。本研究比较了96名有和没有遗传危险因素SOD 2（rs 4880）和CAT（rs 1001179）的老年人的白色微结构和认知差异。结果显示，较高的径向扩散率在前丘脑辐射SOD 2 CC基因型相比，CT/TT基因型。此外，CC基因型调节海马扣带和处理速度之间的关系，虽然这没有生存多次测试校正。CAT多态性与该队列中的脑结果无关。这些结果表明，SOD 2的CC基因型是健康个体次优脑老化的重要遗传标记。
Oxidative stress is a key mechanism of the aging process that can cause damage to brain white matter and cognitive functions. Polymorphisms in the superoxide dismutase 2 (SOD2) and catalase (CAT) genes have been associated with abnormalities in antioxidant enzyme activity in the aging brain, suggesting a risk for enhanced oxidative damage to white matter and cognition among older individuals with these genetic variants. The present study compared differences in white matter microstructure and cognition among 96 older adults with and without genetic risk factors of SOD2 (rs4880) and CAT (rs1001179). Results revealed higher radial diffusivity in the anterior thalamic radiation among SOD2 CC genotypes compared to CT/TT genotypes. Further, the CC genotype moderated the relationship between the hippocampal cingulum and processing speed, though this did not survive multiple test correction. The CAT polymorphism was not associated with brain outcomes in this cohort. These results suggest that the CC genotype of SOD2 is an important genetic marker of suboptimal brain aging in healthy individuals.
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影响因子：
9.9
作者：
Baker, Laurie M.;Laidlaw, David H.;Paul, Robert H.
通讯作者：
Paul, Robert H.
影响因子：
--
作者：
Bartzokis, G;Beckson, M;Mintz, J
通讯作者：
Mintz, J
精神分裂症中道缺陷的分布。
影响因子：
4.4
作者：
Ellison-Wright I;Nathan PJ;Bullmore ET;Zaman R;Dudas RB;Agius M;Fernandez-Egea E;Müller U;Dodds CM;Forde NJ;Scanlon C;Leemans A;McDonald C;Cannon DM
通讯作者：
Cannon DM
影响因子：
4.2
作者：
Cremers, Lotte G. M.;de Groot, Marius;Ikram, M. Arfan
通讯作者：
Ikram, M. Arfan
影响因子：
4.8
作者：
Bennett, Ilana J.;Madden, David J.;Vaidya, Chandan J.;Howard, Darlene V.;Howard, James H., Jr.
通讯作者：
Howard, James H., Jr.