Omega-3 supplementation lowers inflammation and anxiety in medical students: a randomized controlled trial.
Omega-3 supplementation lowers inflammation and anxiety in medical students: a randomized controlled trial.
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DOI：
10.1016/j.bbi.2011.07.229
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发表时间：
2011-11
影响因子：
15.1
通讯作者：
Glaser, Ronald
中科院分区：
文献类型：
--
作者：
Kiecolt-Glaser, Janice K.;Belury, Martha A.;Andridge, Rebecca;Malarkey, William B.;Glaser, Ronald
关键词：
观察性研究将较低的omega-3（n-3）多不饱和脂肪酸（PUFA）和较高的omega-6（n-6）PUFA与炎症和抑郁症联系起来，但随机对照试验（RCT）数据混合。为了确定n-3是否减少健康年轻人的促炎细胞因子产生以及抑郁和焦虑症状，该平行组，安慰剂对照，双盲12周RCT比较了n-3补充剂与安慰剂。参与者是68名医学生，他们在压力较低的时期以及考试前几天提供了一系列血液样本。这些学生接受了n-3（2.5 g/d，2085 mg二十碳五烯酸和348 mg二十二碳六烯酸）或安慰剂胶囊，这些胶囊反映了典型美国饮食中的脂肪酸比例。与对照组相比，那些接受n-3的学生显示脂多糖（LPS）刺激的白细胞介素6（IL-6）产生减少了14%，焦虑症状减少了20%，抑郁症状没有显着变化。个人对n-3 PUFA补充剂的吸收和代谢以及依从性不同;因此，计划使用血浆n-6：n-3比率代替治疗组进行的二次分析表明，降低n-6：n-3比率可降低焦虑和减少刺激的IL-6和肿瘤坏死因子α（TNF-α）的产生，以及血清TNF-α的微小差异。这些数据表明，即使在健康的年轻人中，补充n-3也可以减少炎症和焦虑。与n-3补充剂相关的焦虑症状的减少提供了第一个证据，表明n-3可能对没有焦虑症诊断的个体具有潜在的抗焦虑益处。ClinicalTrials.gov标识符：NCT 00519779
Observational studies have linked lower omega-3 (n-3) polyunsaturated fatty acids (PUFAs) and higher omega-6 (n-6) PUFAs with inflammation and depression, but randomized controlled trial (RCT) data have been mixed. To determine whether n-3 decreases proinflammatory cytokine production and depressive and anxiety symptoms in healthy young adults, this parallel group, placebo-controlled, double-blind 12-week RCT compared n-3 supplementation with placebo. The participants, 68 medical students, provided serial blood samples during lower-stress periods as well as on days before an exam. The students received either n-3 (2.5 g/d, 2085 mg eicosapentaenoic acid and 348 mg docosahexanoic acid) or placebo capsules that mirrored the proportions of fatty acids in the typical American diet. Compared to controls, those students who received n-3 showed a 14% decrease in lipopolysaccharide (LPS) stimulated interleukin 6 (IL-6) production and a 20% reduction in anxiety symptoms, without significant change in depressive symptoms. Individuals differ in absorption and metabolism of n-3 PUFA supplements, as well as in adherence; accordingly, planned secondary analyses that used the plasma n-6:n-3 ratio in place of treatment group showed that decreasing n-6:n-3 ratios led to lower anxiety and reductions in stimulated IL-6 and tumor necrosis factor alpha (TNF-α) production, as well as marginal differences in serum TNF-α. These data suggest that n-3 supplementation can reduce inflammation and anxiety even among healthy young adults. The reduction in anxiety symptoms associated with n-3 supplementation provides the first evidence that n-3 may have potential anxiolytic benefits for individuals without an anxiety disorder diagnosis. ClinicalTrials.gov identifier: NCT00519779
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