Relationships of sex hormone levels with leukocyte telomere length in Black, Hispanic, and Asian/Pacific Islander postmenopausal women.
Relationships of sex hormone levels with leukocyte telomere length in Black, Hispanic, and Asian/Pacific Islander postmenopausal women.
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性激素水平与白细胞端粒长度与黑色，西班牙裔和亚洲/太平洋岛民的绝经后妇女之间的关系。
DOI：
10.1111/1753-0407.12577
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发表时间：
2018-06
影响因子：
4.5
通讯作者：
Liu S
中科院分区：
文献类型：
--
作者：
Song Y;Cho M;Brennan KM;Chen BH;Song Y;Manson JE;Hevener AL;You NY;Butch AW;Liu S
性激素可能在特定性别的生物衰老中发挥重要作用。在这项研究中，我们专门研究了循环性激素浓度和白细胞端粒长度(TL)之间的关系。在妇女健康倡议观察队列中，对1124名黑人、444名西班牙裔和289名亚洲/太平洋岛国妇女进行了一项横断面研究。用电化学发光免疫分析法测定雌二醇和睾酮浓度；用定量聚合酶链式反应测定TL。参与研究的女性年龄在50岁到79岁之间。在这个样本中，雌二醇浓度与TL之间没有显著的相关性。总睾酮和游离睾酮与TL之间的相关性因种族/民族而异(总睾酮和游离睾酮的交互作用分别为0.03和0.05)。在黑人和西班牙裔妇女中，总睾酮和游离睾酮浓度与TL无关，而在亚洲/太平洋岛民妇女中，他们的浓度与TL呈负相关(P趋势=0.003)。在针对潜在混杂因素进行调整的多子组分析和多变量模型中，这些相关性似乎很强。在亚洲/太平洋岛民女性中，血清游离睾酮浓度和总睾酮浓度增加一倍分别与缩短202个基点(95%可信区间51-353个基点)和203个基点(95%可信区间50-355个基点)相关。在这一大样本绝经后妇女中，血清雌二醇浓度与白细胞TL无关。在亚洲和太平洋岛民女性中，总的和游离的睾酮浓度与TL呈负相关，但在黑人和西班牙裔女性中则不是，尽管未来的研究重复我们的观察是有必要的，特别是为了解决潜在的种族特定的关系。
Sex hormones may play important roles in sex-specific biological aging. In the study, we specifically examined associations between circulating sex hormone concentrations and leukocyte telomere length (TL). A cross-sectional study was conducted among 1124 Black, 444 Hispanic, and 289 Asian/Pacific Islander women in the Women’s Health Initiative Observational Cohort. Estradiol and testosterone concentrations were measured using electrochemiluminescence immunoassays; TL was measured using quantitative polymerase chain reaction. Women in the study were aged 50–79 years. Estradiol concentrations were not significantly associated with TL in this sample. The associations between total and free testosterone and TL differed by race/ethnicity (Pinteraction = 0.03 and 0.05 for total and free testosterone, respectively). Total and free testosterone concentrations were not associated with TL in Black and Hispanic women, whereas in Asian/Pacific Islander women their concentrations were inversely associated with TL (Ptrend = 0.003 for both). These associations appeared robust in multiple sub-group analyses and multivariable models adjusted for potential confounding factors. In Asian/Pacific Islander women, a doubling of serum free and total testosterone concentrations was associated with a 202-bp shorter TL (95% confidence interval [CI] 51–353 bp) and 203-bp shorter TL (95% CI 50–355 bp), respectively. Serum estradiol concentrations were not associated with leuko-cyte TL in this large sample of postmenopausal women. Total and free testosterone concentrations were inversely associated with TL in Asian/Pacific Islander women, but not in Black and Hispanic women, although future studies to replicate our observations are warranted particularly to address potential ethnicity-specific relationships.
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影响因子：
5.8
作者：
Miller, KK;Rosner, W;Klibanski, A
通讯作者：
Klibanski, A
影响因子：
9.3
作者：
Chen BH;Brennan K;Goto A;Song Y;Aziz N;You NC;Wellons MF;Manson JE;White DL;Butch AW;Liu S
通讯作者：
Liu S
影响因子：
--
作者：
Harte AL;da Silva NF;Miller MA;Cappuccio FP;Kelly A;O'Hare JP;Barnett AH;Al-Daghri NM;Al-Attas O;Alokail M;Sabico S;Tripathi G;Bellary S;Kumar S;McTernan PG
通讯作者：
McTernan PG
癌症死亡率和生存中的性别差异。
DOI：
10.1158/1055-9965.epi-11-0246
发表时间：
2011-08
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Cook MB;McGlynn KA;Devesa SS;Freedman ND;Anderson WF
通讯作者：
Anderson WF
影响因子：
2.9
作者：
Lin, Jue;Kroenke, Candyce H.;Rasgon, Natalie L.
通讯作者：
Rasgon, Natalie L.