Dairy, calcium, vitamin D and ovarian cancer risk in African-American women.
Dairy, calcium, vitamin D and ovarian cancer risk in African-American women.
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非裔美国女性的乳制品、钙、维生素 D 和卵巢癌风险。
DOI：
10.1038/bjc.2016.289
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发表时间：
2016-10-25
影响因子：
8.8
通讯作者：
Bandera, Elisa V.
中科院分区：
文献类型：
--
作者：
Qin, Bo;Moorman, Patricia G.;Alberg, Anthony J.;Barnholtz-Sloan, Jill S.;Bondy, Melissa;Cote, Michele L.;Funkhouser, Ellen;Peters, Edward S.;Schwartz, Ann G.;Terry, Paul;Schildkraut, Joellen M.;Bandera, Elisa V.
此前还没有研究评估过乳制品、乳糖、钙和维生素 D 与非裔美国女性患卵巢癌风险的关系，众所周知，非裔美国女性患卵巢癌的死亡率很高，并且存在钙和维生素 D 缺乏的风险。我们评估了 490 例卵巢癌病例和 656 名年龄和地点匹配的非裔美国人后裔对照的这些关联，这些对照被招募到非裔美国人癌症流行病学研究中，这是一项在美国 11 个地理区域进行的基于人群的病例对照研究。使用多变量逻辑回归模型来估计比值比 (OR) 和 95% 置信区间 (CI)。研究发现，全脂牛奶摄入量和乳糖摄入量会增加卵巢癌风险（最高四分位数与最低四分位数：OR=1.97，95% CI：1.25–3.10；P 趋势：0.008）。钙摄入量与卵巢癌风险降低相关（OR=0.51，95 CI%：0.30-0.86；P 趋势：0.009），但维生素 D 摄入量则不然。研究发现，夏季较长时间的阳光照射可预测较低的风险（OR=0.71，95% CI：0.51-0.99；P 趋势：0.049）。我们的研究结果表明，高钙、低乳糖饮食和夏季阳光照射可能会降低非裔美国女性患卵巢癌的风险。
No previous study has evaluated the associations of dairy products, lactose, calcium and vitamin D with the risk of ovarian cancer in African–American women, who are known to have high mortality from the disease, as well as to be at risk for calcium and vitamin D deficiency. We evaluated these associations among 490 ovarian cancer cases and 656 age- and site-matched controls of African–American descent recruited into the African American Cancer Epidemiology Study, a population-based case-control study in 11 geographical areas in the US. Multivariable logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). An increased ovarian cancer risk was observed for whole milk consumption and lactose intake (highest quartile vs lowest: OR=1.97, 95% CI: 1.25–3.10;P-trend: 0.008). Calcium intake was associated with a decreased risk of ovarian cancer (OR=0.51, 95 CI%: 0.30–0.86; P-trend: 0.009), but vitamin D intake was not. Longer sun exposure in summer months was found to predict a lower risk (OR=0.71, 95% CI: 0.51–0.99; P-trend: 0.049). Our findings suggest that a high-calcium, low-lactose diet, and sun exposure in summer months may reduce the risk of ovarian cancer in African–American women.
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