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Structural and functional studies to elucidate the role of the DOCK180 pathway in cell polarity, myoblast fusion and podocyte integrity

Structural and functional studies to elucidate the role of the DOCK180 pathway in cell polarity, myoblast fusion and podocyte integrity
结构和功能研究阐明 DOCK180 通路在细胞极性、成肌细胞融合和足细胞完整性中的作用
批准号：
200129
负责人：
Côt Jean-François
金额：
$55.67万
依托单位：
Institut de recherches cliniques de Montral
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2010
资助国家：
加拿大
项目状态：
已结题
起止时间：
2010-03-01 至 2015-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=200129&lang=en
关键词：
Auto-Inhibition Cell Migration Cell Polarization Dock180 Elmo Myoblast Fusion Podocyte Rac Gtpases Signal Transduction Structural Biology

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英文摘要
DOCK180, an evolutionarily conserved protein, acts in concert with ELMO in regulating the activity of the small GTPases of the Rac family. Work in model organisms uncovered a role for these proteins in crucial developmental processes such as cell migratio
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