Radiolabelled MMP binding agents for the identification, quantification, and targeting of MMPs in central nervous system (CNS) disorders and tumours

放射性标记的 MMP 结合剂，用于中枢神经系统 (CNS) 疾病和肿瘤中 MMP 的识别、定量和靶向

• 批准号: DP1094232
• 负责人: Em/Prof Trevor Hambley
• 金额: $ 29.89万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-28 至 2013-01-26
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1094232
• 关键词: Radiolabelled; MMP; binding; agents; identification

Cancer and diseases of the central nervous system (CNS) represent two of the major health challenges facing Australia because of the aging population. In order to address these challenges we need to develop methods for identifying tumours and CNS diseases using non-invasive technologies and at an early stage so that treatments can be applied when they are most likely to work. In this project, we are developing new radiolabelled compounds that will enable the imaging of tumours, tumour metastases and CNS diseases states.

由于人口老龄化，癌症和中枢神经系统（CNS）疾病是澳大利亚面临的两大健康挑战。为了应对这些挑战，我们需要开发利用非侵入性技术在早期阶段识别肿瘤和中枢神经系统疾病的方法，以便在最有可能发挥作用时进行治疗。在这个项目中，我们正在开发新的放射性标记化合物，这些化合物将能够对肿瘤、肿瘤转移和中枢神经系统疾病状态进行成像。