Fluorescent sensing of the intracellular redox environment
Fluorescent sensing of the intracellular redox environment
批准号:
DP180101897
负责人:
Em/Prof Trevor Hambley
金额:
$25.34万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2020-12-31
中文摘要
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英文摘要
This project aims to develop chemical approaches to measure the redox environment of living cells. Oxidation and reduction (redox) reactions are crucial for cellular health and disease and the redox status of cells is known to affect their response to external stress, but surprisingly there remains no way of efficiently and accurately determining cellular redox environments. In this project, new fluorescent redox sensors will be designed and incorporated into assays that enable high-throughput analysis of cell types. These fundamental chemical and biochemical studies could provide the basis of future research into how redox environment can be used as a predictor for disease and therapeutic outcomes.
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