Development and Biological Chemistry of Novel Platinum Anti-Cancer Agents

新型铂类抗癌药物的开发及生物化学

• 批准号: DP0344085
• 负责人: Em/Prof Trevor Hambley
• 金额: $ 10.47万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-03-01 至 2006-02-28
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0344085
• 关键词: Development; Biological; Chemistry; Novel; Platinum

"Rule-breakers", platinum anticancer complexes that do not follow the well established structure/activity relationships, have emerged as the way forward in the treatment of cancer resistant to the current generation of drugs and in reducing side effects. We have developed two new groups of "rule-breakers" and these have already demonstrated highly promising anticancer activity and novel biological behaviour. In this project we will (i) prepare new anticancer active platinum complexes based on these two highly promising groups of compounds and (ii) determine how these drugs work and what happens to them when in biological environments.

“规则破坏者”，即不遵循良好建立的结构/活性关系的铂抗癌复合物，已经成为治疗对当前一代药物具有抗性的癌症和减少副作用的前进方向。我们已经开发了两组新的“规则破坏者”，这些已经证明了非常有前途的抗癌活性和新的生物学行为。在这个项目中，我们将（i）基于这两组非常有前途的化合物制备新的抗癌活性铂络合物，（ii）确定这些药物如何工作以及在生物环境中会发生什么。