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Development of prodrug strategies for achieving increased penetration and selective activation in solid tumours

Development of prodrug strategies for achieving increased penetration and selective activation in solid tumours
开发前药策略以实现实体瘤中增加的渗透和选择性激活
批准号:
DP110100461
负责人:
Em/Prof Trevor Hambley
金额:
$25.33万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-13 至 2014-12-31

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中文摘要
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英文摘要
A primary cause of cancer deaths is relapse following treatment resulting from the drug failing to penetrate and destroy all parts of the tumour. The project aims to develop anticancer agents that are better able to reach all parts of the tumour and have toxicities low enough to enable sufficient doses to be used to kill all cancer cells.
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Fluorescent sensing of the intracellular redox environment
  • 批准号:
    DP180101897
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $25.34万
  • 财政年份:
    2018
  • 负责人:
    Em/Prof Trevor Hambley
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Novel platinum(IV) complexes that are targeted to and trapped by tumours and tumour cells
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    DP140101574
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    $31.45万
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    2014
  • 负责人:
    Em/Prof Trevor Hambley
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Radiolabelled MMP binding agents for the identification, quantification, and targeting of MMPs in central nervous system (CNS) disorders and tumours
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  • 资助金额:
    $29.89万
  • 财政年份:
    2010
  • 负责人:
    Em/Prof Trevor Hambley
  • 依托单位:
Rational Optimisation of the Uptake of Metal-Based Anti-Cancer Agents by Tumours
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    DP0773953
  • 项目类别:
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    $20.82万
  • 财政年份:
    2007
  • 负责人:
    Em/Prof Trevor Hambley
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国内基金
海外基金
以胆酸为载体的肝靶向阿德福韦前体药物的研究
神经病理性疼痛治疗药物的设计与合成