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Effects of Proviral Integration Site for Moloney Murine Leukemia Virus (PIM) Kinases and Zipper Interacting Protein Kinase (ZIPK) inhibition on the development of colonic inflammation and fibrosis

Effects of Proviral Integration Site for Moloney Murine Leukemia Virus (PIM) Kinases and Zipper Interacting Protein Kinase (ZIPK) inhibition on the development of colonic inflammation and fibrosis
莫洛尼鼠白血病病毒 (PIM) 激酶和拉链相互作用蛋白激酶 (ZIPK) 的前病毒整合位点抑制对结肠炎症和纤维化发展的影响
批准号：
367067
负责人：
Chen Tina H
金额：
$1.27万
依托单位：
University of Calgary
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2016
资助国家：
加拿大
项目状态：
已结题
起止时间：
2016-12-01 至 2017-12-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=367067&lang=en
关键词：
Cell Differentiation Cell Proliferation Chronic Inflammation Epithelial-Mesenchymal Transition Fibrosis Inflammatory Bowel Disease (Ibd) Intestinal Epithelial Barrier Pim Kinases T Helper Cells Zipper-Interacting Protein Kinase (Zipk)

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Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), affects 1 in every 150 Canadians. The chronic inflammation is associated with fibrosis and stricture development, a complication that necessitates surgery for ~5
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