Electron cryomicroscopy analysis of erythrocyte Anion Exchanger 1 (AE1), its interaction with erythrocyte cytoskeletal proteins, and its recognition by proteins from malaria-causing Plasmodium parasites.

电子冷冻显微镜分析红细胞阴离子交换蛋白 1 (AE1)、其与红细胞细胞骨架蛋白的相互作用，以及引起疟疾的疟原虫寄生虫的蛋白对它的识别。

• 批准号: 377151
• 负责人: Abbas Yazan
• 金额: $ 9.83万
• 依托单位: Hospital for Sick Children (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-11-01 至 2020-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=377151&lang=en
• 关键词: Biochemistry; Biophysics; Electron Cryomicroscopy; Hereditary Spherocytosis; Ion Transport; Malaria; Membrane Glycoproteins; Red Blood Cell; Structural Biology; Vaccine

Anion Exchanger 1 (AE1) is a red blood cell membrane protein that anchors the skeleton of the cell to its membrane, through interactions that are important for maintaining the shape and function of red blood cells. Genetic defects in AE1 and other red blo

阴离子交换器1(AE1)是一种红细胞膜蛋白，通过对维持红细胞的形状和功能至关重要的相互作用，将细胞的骨架锚定在其膜上。AE1和其他红斑的遗传缺陷