Variation in G protein expression in bone cells determines bone quality and skeletal responses to catabolic and anabolic stimuli

骨细胞中 G 蛋白表达的变化决定骨质量和骨骼对分解代谢和合成代谢刺激的反应

• 批准号: 414111
• 负责人: Mitchell Jane A
• 金额: $ 7.29万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-09-01 至 2020-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=414111&lang=en
• 关键词: Bone; Bone Fracture Healing; Bone Strength; Exercise; G Proteins; Menopause; Signaling

Poor bone health is a major issue in the aging Canadian population, in which 2 million people (1 in 3 postmenopausal women and 1 in 6 older men)1 have osteoporosis and half will have a fragility fracture. Hip fractures in people over 65 years of age signi

骨骼健康状况不佳是加拿大老龄化人口中的一个主要问题，其中200万人（1/3的绝经后妇女和1/6的老年男性）1患有骨质疏松症，一半人将发生脆性骨折。65岁以上人群的髋部骨折