Deploying ONC national Standards in Support of Metadata for Big Data Research Warehouse Management of Repurposed Laboratory, Pathology & Patient Findings Data From the EHR.

部署 ONC 国家标准以支持改造实验室、病理学大数据研究仓库管理的元数据

基本信息

项目摘要

A critical component of the Federal architecture for the Nationwide Health Information Network is the Electronic Health Record (EHR) employing structured clinical data encoded with Office of the National Coordinator (ONC) standard reference terminologies that support interoperable repurposing of the data for research and public health. These reference terminologies, including SNOMED CT and RXNORM, are large and complex, thereby complicating and historically limiting terminology implementation in support of big data research objectives. This research and development proposal seeks to: a) expand the scope and clinical applicability of these terminologies, b) create metadata tooling in support of ONC reference terminology deployment in clinical data repositories (CDR) and c) assess the utility of that deployment for organizing tissue biobanks and supporting networked research queries. Metadata and software tooling will be developed and made available to the biomedical research community through the National Center for Biomedical Ontologies (NCBO). The harmonization of SNOMED CT and LOINC in the domain of observable entities is an important unification of ONC clinical ontologies. This project will expedite this harmonization to include the domains of anatomic pathology, molecular genetics and microbiology and create an observables ontology for distribution through the NCBO. Distribution and implementation of an observables ontology will facilitate research that binds patient phenomic data with disease specific genomic observations in support of research into the genetic basis of disease. The observables ontology will be tested within an i2b2-based CDR in the areas of breast cancer and antimicrobial stewardship. The Patient Centered Outcome Research Initiative (PCORI) seeks to provide timely answers to the research questions of our day by standardizing datasets across research institutions. While employing a common clinical data model, efficient and interoperable query of data employing ONC reference terminologies requires expanded information models, coordination between EHR vendors and shared network protocols. This proposal will deploy the ONC reference terminology metadata including the observables ontology to members of the Greater Plains Consortium (GPC) PCORnet CDRN. Breast cancer and antimicrobial stewardship queries will be deployed between collaborating GPC members for testing of interoperability and demonstration of network functionality.
全国健康信息联邦架构的重要组成部分 网络是使用结构化临床数据编码的电子健康记录(EHR) 国家协调员办公室(ONC)支持的标准参考术语 可互操作的数据再利用,用于研究和公共卫生。这些参考文献 术语,包括SNOMED CT和RXNORM,既大又复杂,因此 使支持大数据研究的术语实施复杂化并在历史上受到限制 目标。这项研究和开发建议寻求:a)扩大范围和临床 这些术语的适用性,b)创建元数据工具以支持ONC参考 临床数据仓库(CDR)中的术语部署和c)评估其实用性 用于组织组织生物库和支持联网研究查询的部署。 将开发元数据和软件工具,并将其用于生物医学研究 社区通过国家生物医学本体论中心(NCBO)。 SNOMED CT和LOINC在可观测实体领域的协调是 ONC临床本体论的重要统一。该项目将加快这一协调 包括解剖病理学、分子遗传学和微生物学领域,并创造 通过NCBO分发的可观测本体论。的分发和实施 可观察的本体论将促进将患者的表象数据与疾病绑定的研究 支持疾病遗传基础研究的特定基因组观察。这个 可观察到的本体论将在基于i2b2的CDR中测试乳腺癌和 抗菌管理。 以患者为中心的结果研究倡议(PCORI)寻求提供及时的 通过标准化研究中的数据集来回答当今的研究问题 机构。在使用通用临床数据模型的同时,高效且可互操作的查询 使用ONC参考术语的数据需要扩展的信息模型, EHR供应商和共享网络协议之间的协调。这项提案将部署 ONC参考术语元数据,包括可观测本体 大平原联盟(GPC)PCORnet CDRN。乳腺癌与抗菌药 将在协作的GPC成员之间部署管理查询,以测试 网络功能的互操作性和演示。

项目成果

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Walter Scott Campbell其他文献

Walter Scott Campbell的其他文献

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{{ truncateString('Walter Scott Campbell', 18)}}的其他基金

Deploying ONC national Standards in Support of Metadata for Big Data Research Warehouse Management of Repurposed Laboratory, Pathology & Patient Findings Data From the EHR.
部署 ONC 国家标准以支持改造实验室、病理学大数据研究仓库管理的元数据
  • 批准号:
    9161358
  • 财政年份:
    2016
  • 资助金额:
    $ 44.86万
  • 项目类别:

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