Epigenetic mechanisms regulating sex differences in fear-related learning and memory

表观遗传机制调节恐惧相关学习和记忆的性别差异

• 批准号: DP1096148
• 负责人: Prof Timothy Bredy
• 金额: $ 50.14万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1096148
• 关键词: Epigenetic; mechanisms; regulating; sex; differences

Anxiety disorders represent an enormous burden on society and are associated with premature aging and infertility in men and women. Evidence also indicates that parental anxiety affects child development. Given that fear-related learning has an important influence on emotional health which, in turn, affects lifestyle and the aging process, an understanding of the neural mechanisms mediating sex differences in fear learning will enhance our ability to develop better therapeutic approaches for treating anxiety and preventing relapse, potentially through a gender-specific approach. The studies outlined in this proposal will have implications for promoting and maintaining good health.

焦虑症是社会的巨大负担，与男性和女性的早衰和不孕有关。证据还表明，父母的焦虑会影响孩子的发展。考虑到与恐惧相关的学习对情绪健康有重要影响，进而影响生活方式和衰老过程，对恐惧学习中调节性别差异的神经机制的理解，将增强我们开发更好的治疗方法来治疗焦虑和预防复发的能力，有可能通过一种针对性别的方法。本建议概述的研究将对促进和保持良好的健康产生影响。