Cell-type specific profiling of nascent RNA in the brain during learning

学习过程中大脑中新生 RNA 的细胞类型特异性分析

• 批准号: DP180102998
• 负责人: Prof Timothy Bredy
• 金额: $ 28.47万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-03-06 至 2021-12-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180102998
• 关键词: Cell; type; specific; profiling; nascent

This project aims to understand cell-type specific, fast-acting, and dynamic patterns of RNA expression that arise during learning and contribute to the formation of memory. Activity-induced gene expression is central to neural plasticity, learning and memory. The project will apply a new approach, which tags RNA inside living cells. The findings will be broadly applicable and create new opportunities for understanding the true nature of brain adaptation.

该项目旨在了解学习过程中出现的细胞类型特异性，快速作用和动态的RNA表达模式，并有助于记忆的形成。活动诱导的基因表达是神经可塑性、学习和记忆的核心。该项目将采用一种新的方法，在活细胞内标记RNA。这些发现将具有广泛的适用性，并为理解大脑适应的真正本质创造新的机会。