Defining novel neuroepigenetic pathways that influence learning and memory

定义影响学习和记忆的新型神经表观遗传途径

• 批准号: DP190100234
• 负责人: Prof Timothy Bredy
• 金额: $ 30.18万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-10 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190100234
• 关键词: Defining; novel; neuroepigenetic; pathways; influence

This project aims to better understand the functional relationship between epigenetic mechanisms and regulatory RNAs in the brain and how they influence learning and the formation of memory. Activity-induced gene expression is central to neural plasticity, learning, and memory. However, efforts to elucidate the underlying mechanisms in the brain have not been fully resolved. By elucidating the full repertoire of epigenetic mechanisms in the brain during learning and memory formation, the findings of the project will be broadly applicable and create new opportunities for understanding the true nature of brain adaptation.

该项目旨在更好地了解大脑中表观遗传机制和调控RNA之间的功能关系，以及它们如何影响学习和记忆的形成。活动诱导的基因表达是神经可塑性、学习和记忆的核心。然而，阐明大脑中潜在机制的努力尚未完全解决。通过阐明学习和记忆形成过程中大脑中表观遗传机制的全部内容，该项目的研究结果将具有广泛的适用性，并为理解大脑适应的真实性质创造新的机会。