Dynamic DNA structure states and memory formation

动态DNA结构状态和记忆形成

• 批准号: DP210103808
• 负责人: Prof Timothy Bredy
• 金额: $ 32.69万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-12-30 至 2024-12-29
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210103808
• 关键词: Dynamic; DNA; structure; states; memory

Activity-induced gene expression is central to neural plasticity, learning, and memory; however, the underlying mechanisms of these processes in the brain have yet to be fully resolved. The aim of this proposal is to obtain a deeper understanding of the functional relationship between genes and brain function. By elucidating the full repertoire of epigenetic mechanisms in the brain during learning and the formation of memory, it is hoped that the true nature of brain adaptation across the lifespan will be revealed. Findings which may then provide new opportunities to strengthen, maintain and optimise cognitive function.

活动诱导的基因表达是神经可塑性、学习和记忆的核心;然而，大脑中这些过程的潜在机制尚未完全解决。该提案的目的是更深入地了解基因与大脑功能之间的功能关系。通过阐明学习和记忆形成过程中大脑中表观遗传机制的全部内容，人们希望揭示大脑在整个生命周期中适应的真实性质。这些发现可能为加强、维持和优化认知功能提供新的机会。