Single cell imaging of trace elements by laser ablation - inductively coupled plasma - mass spectrometry

激光烧蚀-电感耦合等离子体-质谱法对微量元素进行单细胞成像

• 批准号: LP100200254
• 负责人: Prof Philip Doble
• 金额: $ 24.16万
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-11-18 至 2014-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP100200254
• 关键词: Single; cell; imaging; trace; elements

The precise mechanism of how many diseases function on the cellular level is not well understood. Trace elements are important to normal cellular function and have the potential to cause significant damage if delicate levels are disturbed. This project will introduce a new, cost-effective alternative to the synchrotron for mapping of trace elements in single cells. This breakthrough science will transform a common analytical instrument into a powerful new tool for probing the cellular mechanisms of chronic illness. This frontier technology will help determine the role of trace metals in the development of neurodegenerative disease.

许多疾病在细胞水平上起作用的确切机制还不清楚。微量元素对正常细胞功能很重要，如果微妙的水平受到干扰，有可能造成重大损害。该项目将介绍一种新的、具有成本效益的替代同步加速器的方法，用于绘制单细胞中的微量元素。 这一突破性的科学将把一个普通的分析仪器变成一个强大的新工具，用于探索慢性疾病的细胞机制。这项前沿技术将有助于确定微量金属在神经退行性疾病发展中的作用。